The etiopathogenesis of endometriosis is a multifactorial process resulting in a
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …

BACKGROUND DNA damage is a hazard that affects all cells of the body. DNA-damage
repair (DDR) mechanisms are in place to repair damage and restore cellular function, as are …

Pubertal timing varies considerably and is associated with later health outcomes. We
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …

BACKGROUND Our genetic code is now readable, writable and hackable. The recent
escalation of genome-wide sequencing (GS) applications in population diagnostics will not …

Age at menarche (AAM) is an important marker of the pubertal development and function of
the hypothalamic–pituitary–ovarian system. It was reported as a possible factor for a risk of …

We provide the first analysis and synthesis of the evolutionary and mechanistic bases for risk
of endometriosis in humans, structured around Niko Tinbergen's four questions about …

Objectives To study associations candidate genes for age at menarche with a risk of
endometrial hyperplasia (EH). Methods 52 candidate loci for age at menarche were …

The present study was designed to examine whether sex hormone polymorphisms proven
by GWAS are associated with endometriosis risk. Unrelated female participants totaling …

Research question Are the candidate genes for age at menarche associated with a risk of
endometriosis? Design Fifty-two candidate single nucleotide polymorphisms (SNP) for age …

Background Oocyte maturation arrest and early embryonic arrest are important reproductive
phenotypes resulting in female infertility and cause the recurrent failure of assisted …