Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …

The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …

Since high-affinity adenosine A2 receptors (A2a) are localized exclusively in dopamine-rich
regions in the central nervous system and mediate inhibition of locomotor activity, we have …

The purine nucleoside adenosine acts via four distinct adenosine receptor subtypes: the
adenosine A1, A2A, A2B, and A3 receptor. They are all G protein-coupled receptors (GPCR) …

Cardiomyocytes and vascular cells readily form, transport, and metabolize the endogenous
adenine nucleoside adenosine and act to regulate both interstitial and plasma adenosine …

A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

CD73 or ecto‐5′‐nucleotidase (S‐NT) is a widely expressed ecto‐enzyme which catalyzes
the dephosphorylation of AMP and other nucleoside monophosphates. CD 73 participates in …