Human listeriosis
MM Koopmans, MC Brouwer… - Clinical Microbiology …, 2023 - Am Soc Microbiol
Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that can cause
severe invasive infections upon ingestion with contaminated food. Clinically, listerial …
severe invasive infections upon ingestion with contaminated food. Clinically, listerial …
Defining memory CD8 T cell
MD Martin, VP Badovinac - Frontiers in immunology, 2018 - frontiersin.org
CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …
cells differing in phenotype and function. This review will focus on our current understanding …
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans
CB Kurtz, YA Millet, MK Puurunen… - Science translational …, 2019 - science.org
The intestine is a major source of systemic ammonia (NH3); thus, capturing part of gut NH3
may mitigate disease symptoms in conditions of hyperammonemia such as urea cycle …
may mitigate disease symptoms in conditions of hyperammonemia such as urea cycle …
Engineering bacteria for diagnostic and therapeutic applications
Our ability to generate bacterial strains with unique and increasingly complex functions has
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …
Making sense of the biodiversity and virulence of Listeria monocytogenes
Listeria monocytogenes is a foodborne pathogen responsible for listeriosis, an infection that
can manifest in humans as bacteremia, meningoencephalitis in immunocompromised …
can manifest in humans as bacteremia, meningoencephalitis in immunocompromised …
Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice
BC Selvanesan, D Chandra… - Science translational …, 2022 - science.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are
poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor …
poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor …
Monocyte recruitment during infection and inflammation
Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to
peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave …
peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave …
Gut microbiota promote hematopoiesis to control bacterial infection
The commensal microbiota impacts specific immune cell populations and their functions at
peripheral sites, such as gut mucosal tissues. However, it remains unknown whether gut …
peripheral sites, such as gut mucosal tissues. However, it remains unknown whether gut …
Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection
Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors
of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria …
of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria …
Immunology of the maternal-fetal interface
A Erlebacher - Annual review of immunology, 2013 - annualreviews.org
The immune cells that reside at the interface between the placenta and uterus are thought to
play many important roles in pregnancy. Recent work has revealed that the composition and …
play many important roles in pregnancy. Recent work has revealed that the composition and …