Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Abstract microRNA-mediated direct cardiac reprogramming, directly converts fibroblasts into
induced cardiomyocyte-like cells (iCMs), which holds great promise in cardiac regeneration …

Solid cancers such as breast tumors comprise a collection of tumor, stromal and immune
cells, embedded within a network of tumor-specific extracellular matrix. This matrix is …

Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death
worldwide. Acute MI (AMI) inflicts massive injury to the coronary microcirculation, causing …

Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary vascular disease
characterized by progressive pulmonary artery pressure elevation, increased pulmonary …

Tenascin-C (TNC) is a large extracellular matrix glycoprotein classified as a matricellular
protein that is generally upregulated at high levels during physiological and pathological …

Myocardial ischemia and infarction, both in the acute and chronic phases, are associated
with cardiomyocyte loss and dramatic changes in the cardiac extracellular matrix (ECM). It …

BACKGROUND Type 2 diabetes mellitus (T2DM) is significantly increasing worldwide, and
the incidence of its complications is also on the rise. One of the main complications of T2DM …