Background Mutations in SOD1 cause 13% of familial amyotrophic lateral sclerosis. In the
SOD1 Gly93Ala rat model of amyotrophic lateral sclerosis, the antisense oligonucleotide …

At the turn of the last century, the emerging field of medical oncology chose a cytotoxic
approach to cancer therapy over an immune-centered approach at a time when evidence in …

Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …

CD133 marks self-renewing cancer stem cells (CSCs) in a variety of solid tumors, and
CD133+ tumor-initiating cells are known markers of chemo-and radio-resistance in multiple …

Simple Summary This review describes in a very detailed and exhaustive approach the
literature of these last 20 years on glioblastoma targeted therapies in Phases II-IV of 257 …

Gliomas are the most common primary brain tumors. Particularly in adult patients, the vast
majority of gliomas belongs to the heterogeneous group of diffuse gliomas, ie. glial tumors …

TGF-beta signaling is one of the major pathways controlling cell and tissue behavior not only
in homeostasis but also in disease. During tumorigenesis TGF-beta orchestrated processes …

Glioblastoma (GBM) is a lethal and aggressive brain tumor that is resistant to conventional
radiation and cytotoxic chemotherapies. Molecularly targeted agents hold great promise in …

The TGF-β (transforming growth factor-β) system signals via protein kinase receptors and
Smad mediators to regulate a plethora of biological processes, including morphogenesis …

Distant metastasis is the main cause of breast cancer-related death; however, effective
therapeutic strategies targeting metastasis are still scarce. This is largely attributable to the …