Glioblastoma multiforme (GBM) is one of the most frequently occurring tumors in the central
nervous system and the most malignant tumor among gliomas. Despite aggressive …

Highlights•Innate mesenchymal-stroma maintains a tumor-suppressive homeostatic
equilibrium.•Fibroblastic-ECM interplay is referred to as stromal dynamic reciprocity.• …

An intact immune system is essential to prevent the development and progression of
neoplastic cells in a process termed immune surveillance. During this process the innate …

Effective treatment of glioblastoma (GBM) remains a formidable challenge. Survival rates
remain poor despite decades of clinical trials of conventional and novel, biologically …

Convection-enhanced delivery (CED) is a method used to increase transport of therapeutics
in and around brain tumors. CED works through locally applying a pressure differential to …

Mortality and morbidity in patients with solid tumors invariably result from the disruption of
normal biological function caused by disseminating tumor cells. Tumor cell migration is …

Treatment of glioblastoma (GBM), the most common primary malignant brain tumor in adults,
remains a significant unmet need in oncology. Historically, cytotoxic treatments provided …

Osteosarcomas are the most prevalent malignant primary bone tumors in children. Despite
intensive efforts to improve both chemotherapeutics and surgical management, 40% of all …

Cancer is not only composed malignant epithelial component but also stromal components
such as fibroblasts, endothelial cells, and inflammatory cells, by which an appropriate tumor …

Abstract Micro RNA‐10b (miR‐10b) is a unique oncogenic mi RNA that is highly expressed
in all GBM subtypes, while absent in normal neuroglial cells of the brain. miR‐10b inhibition …