Identification of carbazole alkaloid derivatives with acylhydrazone as novel anti-TMV agents with the guidance of a digital fluorescence visual screening

X Zhang, W Huang, X Lu, S Liu, H Feng… - Journal of Agricultural …, 2021 - ACS Publications
Difficulty in preventing crops from plant viruses urges to discover novel efficient antiviral
chemicals, which is sped up by precise screening methods. Fluorescence-based methods …

Synthesis of Tylocrebrine and Related Phenanthroindolizidines by VOF3-Mediated Oxidative Aryl-Alkene Coupling

MJ Niphakis, GI Georg - Organic Letters, 2011 - ACS Publications
A highly convergent strategy to prepare phenanthroindolizidines is reported involving three
consecutive C− C coupling reactions. This sequence features a novel VOF3-mediated aryl …

Design, synthesis, antiviral activity, and SARs of 13a-substituted phenanthroindolizidine alkaloid derivatives

B Su, C Cai, M Deng, D Liang, L Wang… - Bioorganic & Medicinal …, 2014 - Elsevier
On the basis of our previous structure–activity relationship (SAR) and antiviral mechanism
studies, a series of 13a-substituted phenanthroindolizidine alkaloid analogues (3a–16a, 3b …

Spatial configuration and three-dimensional conformation directed design, synthesis, antiviral activity, and structure–activity relationships of phenanthroindolizidine …

B Su, C Cai, M Deng, Q Wang - Journal of agricultural and food …, 2016 - ACS Publications
Our recent investigation on the antiviral activities against tobacco mosaic virus (TMV) of
phenanthroindolizidine alkaloid analogues preliminarily revealed that the basic skeleton …

A five-step synthesis of (±)-tylophorine via a nitrile-stabilized ammonium ylide

G Lahm, A Stoye, T Opatz - The Journal of Organic Chemistry, 2012 - ACS Publications
A Five-Step Synthesis of (±)-Tylophorine via a Nitrile-Stabilized Ammonium Ylide | The Journal
of Organic Chemistry ACS ACS Publications C&EN CAS Find my institution Log In The Journal …

Discovery and Nanosized Preparations of (S,R)-Tylophorine Malate as Novel anti-SARS-CoV-2 Agents

Z Wang, F Ye, Y Feng, W Xiao, H Song… - ACS Medicinal …, 2021 - ACS Publications
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has stimulated the search for effective drugs for its …

Synthesis of alkaloids by stevens rearrangement of nitrile-stabilized ammonium ylides:(±)-laudanosine,(±)-laudanidine,(±)-armepavine,(±)-7-methoxycryptopleurine …

JC Orejarena Pacheco, G Lahm… - The Journal of Organic …, 2013 - ACS Publications
The Stevens rearrangement of nitrile-stabilized ammonium ylides in conjunction with the
reductive removal of the nitrile function permits the facile construction of α-branched amines …

Benzoindolizidine Alkaloids Tylophorine and Lycorine and Their Analogues with Antiviral, Anti-Inflammatory, and Anticancer Properties: Promises and Challenges

A Di Sotto, M Valipour, A Azari, S Di Giacomo… - Biomedicines, 2023 - mdpi.com
Ongoing viral research, essential for public health due to evolving viruses, gains
significance owing to emerging viral infections such as the SARS-CoV-2 pandemic. Marine …

Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine

MJ Niphakis, GI Georg - The Journal of organic chemistry, 2010 - ACS Publications
This paper presents the first application of two recently developed reactions to natural
product synthesis. The first method involves a 6-endo-trig cyclization to prepare a versatile …

Design, synthesis, and bioactivity study of novel tryptophan derivatives containing azepine and acylhydrazone moieties

J Zhang, R Yang, L Li, J Liu, Y Liu, H Song, Q Wang - Molecules, 2022 - mdpi.com
Based on the scaffolds widely used in drug design, a series of novel tryptophan derivatives
containing azepine and acylhydrazone moieties have been designed, synthesized …