Based on the scaffolds widely used in drug design, a series of novel tryptophan derivatives
containing 2, 5-diketopiperazine and acyl hydrazine moieties have been designed …

Background Respiratory infections continue to rank among the leading global causes of
death, and the emergence of new infectious respiratory diseases remains a persistent …

The first enantioselective approach to 13a-methylphenanthroindolizidine alkaloids is
reported, featuring an efficient stereoselective Seebach's alkylation and Pictet–Spengler …

Tobacco mosaic virus (TMV) represents a paradigm in virology, and its control may open the
way to effective treatment against phytoviruses. However, the use of chemicals to eliminate …

A series of trans-3-aryl acrylic acids 1–27 and their derivatives 28–34 were prepared and
evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The …

Macrophages are important therapeutic targets for various disorders, including infectious
diseases, inflammatory diseases, metabolic diseases, and cancer. In this study, we report a …

The enantioselective synthesis of phenanthroquinolizidine alkaloids cryptopleurine and
boehmeriasin A was achieved in eight steps from commercial available Cbz-protected 2 …

Glycoconjugates of phenanthroindolizidine alkaloids targeting tobacco mosaic virus (TMV)
RNA were designed, synthesized, and evaluated for their antiviral activity against TMV for …

Caesalpinia decapetala is a versatile medicinal plant belonging to the Fabaceae plant
family. In our survey on plant secondary metabolites to obtain bioactive substances for the …

A series of hydrogenated ferulic acid amide derivatives 4 were synthesized. The molecular
structures of the synthesized compounds were analyzed by 1H NMR and HRMS. The …