From asthma and heart disease to diabetes and obesity, the human microbiome plays a role
in the pathogenesis of each chronic health condition plaguing today's society. Recent work …

Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Regulation of biological processes typically incorporates mechanisms that initiate and
terminate the process and, where understood, these mechanisms often involve feedback …

Abstract Diurnal (ie., 24-hour) oscillations of the gut microbiome have been described in
various species including mice and humans. However, the driving force behind these …

The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …

Rhythmic gene expression is found throughout the central nervous system. This harmonized
regulation can be dependent on-and independent of-the master regulator of biological …

What is addressed as growing season in terrestrial ecosystems is one of the main
determinants of annual plant biomass production globally. However, there is no well …

In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting
cues, adjusting internal∼ 24 h rhythms to resonate with, and anticipate, external cycles of …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently
accompany cardiac disease, yet the underlying mechanism has remained enigmatic …