Abstract The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT)
signaling pathway is utilized by numerous cytokines and interferons, and is essential for the …

Myeloperoxidase (MPO) is the most toxic enzyme found in the azurophilic granules of
neutrophils. MPO utilizes H 2 O 2 to generate hypochlorous acid (HClO) and other reactive …

Summary Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …

The host defence peptide cathelicidin (LL-37 in humans, mCRAMP in mice) is released from
neutrophils by de-granulation, NETosis and necrotic death; it has potent anti-pathogen …

A major function of T helper (Th) 17 cells is to induce the production of factors that activate
and mobilize neutrophils. Although Th17 cells have been implicated in the pathogenesis of …

Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown
to enhance pathogen clearance by recruiting circulating immune cells and providing …

Disruption of the blood–brain and blood–spinal cord barriers (BBB and BSCB, respectively)
and immune cell infiltration are early pathophysiological hallmarks of multiple sclerosis …

Growing evidence supports a role for IL-1 in multiple sclerosis and experimental
autoimmune encephalomyelitis (EAE), but how it impacts neuroinflammation is poorly …

Neutrophils are the most abundant circulating and first-responding innate myeloid cells and
have so far been underestimated in the context of multiple sclerosis (MS). MS is the most …

Autophagy, an intracellular degradation and energy recycling mechanism, is emerging as
an important regulator of immune responses. However, the role of autophagy in regulating …