Studies of complement genetics have changed the landscape of thrombotic
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …

Thrombotic microangiopathy (TMA), a pathological lesion observed in a wide spectrum of
diseases, is triggered by endothelial injury and/or dysfunction. Although TMA lesions are …

Thrombotic microangiopathy (TMA) is a condition characterized by thrombocytopenia and
microangiopathic hemolytic anemia (MAHA) with varying degrees of organ damage in the …

Atypical hemolytic uremic syndrome (aHUS) is a rare but severe disorder that frequently has
a genetic component and results from the overactivation of the alternative complement …

Haemolytic uraemic syndrome (HUS) is a heterogeneous group of diseases that result in a
common pathology, thrombotic microangiopathy, which is classically characterised by the …

Our understanding and management of atypical hemolytic uremic syndrome (aHUS) have
dramatically improved in the last decade. aHUS has been established as a prototypic …

Here, we review the pathogeneses and the corresponding phenotypes of aHUS and
complement-related TMAs. aosylceramide on target cell surface and leads to cytotoxicity …

The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …

Background Hemolytic uremic syndrome (HUS) is a multisystemic disease. In a nationwide
study, we characterized the incidence, clinical course, and prognosis of HUS caused by …

Introduction Recurrence of atypical hemolytic uremic syndrome (aHUS) in renal allografts is
common, leading to dialysis and graft failure. Pretransplant versus posttransplant initiation of …