Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles
RB Fletcher, LD Stokes, IB Kelly III, KM Henderson… - ACS …, 2023 - ACS Publications
The complexity of CRISPR machinery is a challenge to its application for nonviral in vivo
therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge …
therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge …
Silicon nanoparticles with surface nitrogen: 90% quantum yield with narrow luminescence bandwidth and the ligand structure based energy law
Silicon nanoparticles (NPs) have been widely accepted as an alternative material for typical
quantum dots and commercial organic dyes in light-emitting and bioimaging applications …
quantum dots and commercial organic dyes in light-emitting and bioimaging applications …
Addressing the autofluorescence issue in deep tissue imaging by two-photon microscopy: the significance of far-red emitting dyes
The fluorescence imaging of tissue is essential for studying biological events beyond the
cellular level. Two-photon microscopy based on the nonlinear light absorption of fluorescent …
cellular level. Two-photon microscopy based on the nonlinear light absorption of fluorescent …
Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy
KP Tamarov, LA Osminkina, SV Zinovyev… - Scientific reports, 2014 - nature.com
Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF)
radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively …
radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively …
A MACEing silicon: Towards single-step etching of defined porous nanostructures for biomedicine
Metal-assisted chemical etching (MACE) affords porous silicon nanostructures control over
size, shape, and porosity in a single step. Simplicity and flexibility are potential advantages …
size, shape, and porosity in a single step. Simplicity and flexibility are potential advantages …
Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces
Y Jiang, JL Carvalho-de-Souza, RCS Wong, Z Luo… - Nature materials, 2016 - nature.com
Silicon-based materials have widespread application as biophysical tools and biomedical
devices. Here we introduce a biocompatible and degradable mesostructured form of silicon …
devices. Here we introduce a biocompatible and degradable mesostructured form of silicon …
Size-dependent photoluminescence efficiency of silicon nanocrystal quantum dots
Photoluminescence (PL) spectra were measured for dodecene-capped Si nanocrystals with
a wide range of average diameters, from 1.8 to 9.1 nm. Nanocrystals larger than 3 nm …
a wide range of average diameters, from 1.8 to 9.1 nm. Nanocrystals larger than 3 nm …
Recent advances of lanthanide-doped upconversion nanoparticles for biological applications
Near infrared (NIR) excited lanthanide-doped upconversion nanoparticles (UCNPs) are
emerging as a new type of fluorescent tag for biological applications, which can emit multi …
emerging as a new type of fluorescent tag for biological applications, which can emit multi …
In vivo bioluminescence imaging of natural bacteria within deep tissues via ATP-binding cassette sugar transporter
Q Zhang, B Song, Y Xu, Y Yang, J Ji, W Cao… - Nature …, 2023 - nature.com
Most existing bioluminescence imaging methods can only visualize the location of
engineered bacteria in vivo, generally precluding the imaging of natural bacteria. Herein, we …
engineered bacteria in vivo, generally precluding the imaging of natural bacteria. Herein, we …
Porous silicon nanoparticles for nanomedicine: preparation and biomedical applications
The research on porous silicon (PSi) materials for biomedical applications has expanded
greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi …
greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi …