Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles

RB Fletcher, LD Stokes, IB Kelly III, KM Henderson… - ACS …, 2023 - ACS Publications
The complexity of CRISPR machinery is a challenge to its application for nonviral in vivo
therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge …

Silicon nanoparticles with surface nitrogen: 90% quantum yield with narrow luminescence bandwidth and the ligand structure based energy law

Q Li, TY Luo, M Zhou, H Abroshan, J Huang, HJ Kim… - ACS …, 2016 - ACS Publications
Silicon nanoparticles (NPs) have been widely accepted as an alternative material for typical
quantum dots and commercial organic dyes in light-emitting and bioimaging applications …

Addressing the autofluorescence issue in deep tissue imaging by two-photon microscopy: the significance of far-red emitting dyes

YW Jun, HR Kim, YJ Reo, M Dai, KH Ahn - Chemical science, 2017 - pubs.rsc.org
The fluorescence imaging of tissue is essential for studying biological events beyond the
cellular level. Two-photon microscopy based on the nonlinear light absorption of fluorescent …

Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

KP Tamarov, LA Osminkina, SV Zinovyev… - Scientific reports, 2014 - nature.com
Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF)
radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively …

A MACEing silicon: Towards single-step etching of defined porous nanostructures for biomedicine

H Alhmoud, D Brodoceanu, R Elnathan, T Kraus… - Progress in materials …, 2021 - Elsevier
Metal-assisted chemical etching (MACE) affords porous silicon nanostructures control over
size, shape, and porosity in a single step. Simplicity and flexibility are potential advantages …

Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces

Y Jiang, JL Carvalho-de-Souza, RCS Wong, Z Luo… - Nature materials, 2016 - nature.com
Silicon-based materials have widespread application as biophysical tools and biomedical
devices. Here we introduce a biocompatible and degradable mesostructured form of silicon …

Size-dependent photoluminescence efficiency of silicon nanocrystal quantum dots

Y Yu, G Fan, A Fermi, R Mazzaro… - The Journal of …, 2017 - ACS Publications
Photoluminescence (PL) spectra were measured for dodecene-capped Si nanocrystals with
a wide range of average diameters, from 1.8 to 9.1 nm. Nanocrystals larger than 3 nm …

Recent advances of lanthanide-doped upconversion nanoparticles for biological applications

H Li, X Wang, D Huang, G Chen - Nanotechnology, 2019 - iopscience.iop.org
Near infrared (NIR) excited lanthanide-doped upconversion nanoparticles (UCNPs) are
emerging as a new type of fluorescent tag for biological applications, which can emit multi …

In vivo bioluminescence imaging of natural bacteria within deep tissues via ATP-binding cassette sugar transporter

Q Zhang, B Song, Y Xu, Y Yang, J Ji, W Cao… - Nature …, 2023 - nature.com
Most existing bioluminescence imaging methods can only visualize the location of
engineered bacteria in vivo, generally precluding the imaging of natural bacteria. Herein, we …

Porous silicon nanoparticles for nanomedicine: preparation and biomedical applications

HA Santos, E Mäkilä, AJ Airaksinen, LM Bimbo… - …, 2014 - Taylor & Francis
The research on porous silicon (PSi) materials for biomedical applications has expanded
greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi …