Tumor-targeting, microRNA-silencing porous silicon nanoparticles for ovarian cancer therapy

A Bertucci, KH Kim, J Kang, JM Zuidema… - … applied materials & …, 2019 - ACS Publications
Silencing of aberrantly expressed microRNAs (miRNAs or miRs) has emerged as one of the
strategies for molecular targeted cancer therapeutics. In particular, miR-21 is an oncogenic …

Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues

A Tzur-Balter, Z Shatsberg, M Beckerman… - Nature …, 2015 - nature.com
Nanostructured porous silicon (PSi) is emerging as a promising platform for drug delivery
owing to its biocompatibility, degradability and high surface area available for drug loading …

A strategy for developing near infrared long-persistent phosphors: taking MAlO 3: Mn 4+, Ge 4+(M= La, Gd) as an example

Y Li, YY Li, K Sharafudeen, GP Dong… - Journal of Materials …, 2014 - pubs.rsc.org
A wide variety of activation ions have been used as near infrared (NIR) luminescent centres.
However, when it comes to persistent luminescence, the numbers of known activators are …

In Vivo Imaging of Single Tumor Cells in Fast-Flowing Bloodstream Using Near-Infrared Quantum Dots and Time-Gated Imaging

T Pons, S Bouccara, V Loriette, N Lequeux, S Pezet… - ACS …, 2019 - ACS Publications
Whereas in vivo fluorescence imaging of cells immobilized within tissues provides a
valuable tool to a broad range of biological studies, it still lacks the sensitivity required to …

Recent advances in porous nanostructures for cancer theranostics

J Wang, B Zhang, J Sun, W Hu, H Wang - Nano Today, 2021 - Elsevier
Porous nanomaterials with high surface area, tunable porosity, and large mesopores have
recently received particular attention in cancer therapy and imaging. Introduction of …

Strategies to overcome autofluorescence in nanoprobe‐driven in vivo fluorescence imaging

B Del Rosal, A Benayas - Small Methods, 2018 - Wiley Online Library
The development of fluorescent probes and optical detection systems in the near‐infrared
(700–2000 nm) has boosted the interest in fluorescence bioimaging as an alternative to …

Recent advances in surface engineering of porous silicon nanomaterials for biomedical applications

Y Jung, Y Huh, D Kim - Microporous and Mesoporous Materials, 2021 - Elsevier
Surface engineering of the nanomaterials opens a new era of their biomedical applications.
To date, various kinds of nanoparticles and their surface engineering techniques have been …

Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain

J Joo, EJ Kwon, J Kang, M Skalak, EJ Anglin… - Nanoscale …, 2016 - pubs.rsc.org
We report the synthesis, characterization, and assessment of a nanoparticle-based RNAi
delivery platform that protects siRNA payloads against nuclease-induced degradation and …

Recent advances in silicon quantum dot-based fluorescent biosensors

Y Zhang, N Cai, V Chan - Biosensors, 2023 - mdpi.com
With the development of nanotechnology, fluorescent silicon nanomaterials have been
synthesized and applied in various areas. Among them, silicon quantum dots (SiQDs) are a …

Ultrapure laser-synthesized Si-based nanomaterials for biomedical applications: in vivo assessment of safety and biodistribution

T Baati, A Al-Kattan, MA Esteve, L Njim… - Scientific reports, 2016 - nature.com
Abstract Si/SiOx nanoparticles (NPs) produced by laser ablation in deionized water or
aqueous biocompatible solutions present a novel extremely promising object for biomedical …