Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects

A Boccaccini, D Cavaterra, C Carnevale… - Molecular Aspects of …, 2023 - Elsevier
In the last years, neuroprotective therapies have attracted the researcher interests as
modern and challenging approach for the treatment of neurodegenerative diseases, aimed …

[HTML][HTML] Role of epigenetic regulation in glaucoma

L Feng, C Wang, C Zhang, W Zhang, W Song - Biomedicine & …, 2023 - Elsevier
Glaucoma is the world's leading irreversible blinding eye disease. Lowering intraocular
pressure is currently the only effective clinical treatment. However, there is a lack of long …

Reduction-responsive polymeric micelles for trans-corneal targeted delivery of microRNA-21-5p and glaucoma-specific gene therapy

B Han, R Zhang, L Li, C Hu, M Li, J Liu, X Sun… - Journal of Materials …, 2023 - pubs.rsc.org
The therapeutic value of microRNA (miRNA) for the treatment of glaucoma has become a
focus of attention. However, naked miRNA cannot cross the corneal barrier and reach the …

Therapeutic strategies for glaucoma and optic neuropathies

J Lo, K Mehta, A Dhillon, YK Huang, Z Luo… - Molecular aspects of …, 2023 - Elsevier
Glaucoma is a neurodegenerative eye disease that causes permanent vision impairment.
The main pathological characteristics of glaucoma are retinal ganglion cell (RGC) loss and …

Eye-wearable Ti3C2Tx MXene-based microsupercapacitor as power unit for intraocular pressure applications

W Liu, Z Du, Z Duan, H Liu, L Li, K Jiang… - Journal of Materials …, 2024 - pubs.rsc.org
Ocular devices worn on human eyeballs with hemispherical appearance and intelligent
functionals are expected to perform continuous and nondestructive oculopathy disease …

pH-Sensitive Cationic Polymer/DNA Nano-assemblies for Efficient Gene Transfection in Neuroma Cells

L Hu, S Li, Y Lv - ACS Applied Nano Materials, 2023 - ACS Publications
Transfection of functional genetic molecules into neuroma cells to efficiently manipulate
gene expression is of great significance in neuro-associated gene therapy. However, most …

Determinants of participation in glaucoma genomic research in South East Nigeria: A cross-sectional analytical study

NJ Uche, O Okoye, N Kizor-Akaraiwe, C Chuka-Okosa… - Plos one, 2023 - journals.plos.org
Background Genomic research advances the understanding of human health and disease. It
also drives both the discovery of salient genetic association (s) as well as targeted …

Ocular drug delivery-challenges, opportunities, and developments

J Ji, Y Tao, Y Pang - Advanced drug delivery reviews, 2023 - pubmed.ncbi.nlm.nih.gov
Editorial: Ocular Drug delivery - Challenges, Opportunities, and Developments Editorial:
Ocular Drug delivery - Challenges, Opportunities, and Developments Adv Drug Deliv Rev …

Insights into CD154‐mediated pathways in ocular hypertensive glaucoma: The role of Müller cells and P2X7 in retinal neuroprotection and therapeutic potential

H Hu, X Liu, D Nie, M Fang, J Zhang… - Cell biology …, 2023 - Wiley Online Library
An elevation of pathologic intraocular pressure (IOP) is the greatest risk factor for glaucoma.
CD154 has been reported to bind to CD40 expressed by orbital fibroblasts and be involved …

scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of …

HJ Kim, S Cha, JS Choi, JY Lee, KE Kim… - International Journal of …, 2023 - mdpi.com
Elevated intraocular pressure (IOP) in glaucoma causes retinal ganglion cell (RGC) loss and
damage to the optic nerve. Although IOP is controlled pharmacologically, no treatment is …