The effects of atorvastatin on memory deficit and seizure susceptibility in pentylentetrazole-kindled rats

G Üzüm, K Akgün-Dar, U Aksu - Epilepsy & Behavior, 2010 - Elsevier
Deficits in memory function have been observed in pentylentetrazole (PTZ)-kindled rats. In
the present study we examined the effects of atorvastatin ((3-hydroxy-3-methylglutaryl …

Chronic exposure to environmentally relevant levels of simvastatin disrupts zebrafish brain gene signaling involved in energy metabolism

S Barros, AM Coimbra, N Alves, M Pinheiro… - Journal of Toxicology …, 2020 - Taylor & Francis
Simvastatin (SIM), a hypocholesterolaemic drug belonging to the statins group, is a widely
prescribed pharmaceutical for prevention of cardiovascular diseases. Several studies …

High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin

N Okudan, M Belviranli - Brain Research Bulletin, 2020 - Elsevier
Background Statins are cholesterol lowering drugs that decrease the risk of cardiovascular
events, but they are related with a few unfavorable symptoms in skeletal muscle including …

Regulation of cholesterol biosynthetic pathway in different regions of the rat central nervous system

M Segatto, L Trapani, C Lecis, V Pallottini - Acta physiologica, 2012 - Wiley Online Library
Aim In this study, we investigated the regulatory network of the key and rate‐limiting enzyme
of cholesterol biosynthetic pathway, the 3‐hydroxy 3‐methylglutaryl coenzyme A reductase …

The effect of simvastatin and vitamin D Co-Administration on rats brain function and behavior: A behavioral and biochemical study

MS Ranaiy, F Farokhi… - Journal of Advanced …, 2022 - publish.kne-publishing.com
Background & Objective: The simvastatin (Sim) is a lipophilic statin and can cross the blood-
brain barrier. The role of vitamin D (Vit D) in brain development and function has been …

Molecular mechanisms of toxicity of simvastatin, widely used cholesterol-lowering drug. A review

YG Kaminsky, EA Kosenko - Central European journal of medicine, 2010 - Springer
Statins are widely used and well tolerated cholesterol-lowering drugs, and when used for
therapy purposes reduce morbidity and mortality from coronary heart disease. Simvastatin is …

Effects of HMG-CoA reductase inhibitors on learning and memory in the guinea pig

S Maggo, JC Ashton - European Journal of Pharmacology, 2014 - Elsevier
Statins reduce the risk of death from cardiovascular disease in millions of people worldwide.
Recent pharmacovigilance data has suggested that people taking statins have an increased …

The effect of statins on performance in the Morris water maze in guinea pig

S Maggo, D Clark, JC Ashton - European journal of pharmacology, 2012 - Elsevier
Statins play a crucial role in reducing the risk of death from cardiovascular disease in
millions of people worldwide. Recently, pharmacovigilance data has suggested that statin …

Adjuvant effects of classical music on simvastatin induced reduction of anxiety but not object recognition memory in rats

AM Camargo, DD Lima, DD Dal Magro… - Psychology & …, 2013 - SciELO Brasil
Simvastatin is one of many hydroxymethylglutaryl-coenzyme-A reductase inhibitors that are
prescribed to lower cholesterol. Some emerging evidence indicates that classical music can …

Simvastatin promotes cardiac myocyte relaxation in association with phosphorylation of troponin I

DA MacDougall, SD Pugh, HS Bassi… - Frontiers in …, 2017 - frontiersin.org
The number of people taking statins is set to increase across the globe due to recent
changes in prescription guidelines. For example, half the US population over 40 is now …