This Mini-Review Article outlines recent advances in the study of local electric field (LEF)
governed enzyme catalysis and the application of the LEF principle in synthetic catalyst …

Ribonucleoprotein (RNP)‐machineries are comprised of intricate networks of long
noncoding RNAs and proteins that allow them to actively participate in transcription, RNA …

A methyltransferase ribozyme (MTR1) was selected in vitro to catalyze alkyl transfer from
exogenous O 6-methylguanine (O 6mG) to a target adenine N1, and recently, high …

Deoxyribozymes (DNAzymes) are in vitro evolved DNA sequences capable of catalyzing
chemical reactions. The RNA-cleaving 10-23 DNAzyme was the first DNAzyme to be …

Microscopic electrostatic phenomena are widely studied in biology due to the great
importance they have in describing molecular behavior in aqueous environments …

Understanding enzyme mechanisms is essential for unraveling the complex molecular
machinery of life. In this review, we survey the field of computational enzymology …

Sequence-specific recognition of transcription factor (TF) binding motifs in the target site of
DNA over the vast amount of non-target DNA is of primary importance for the transcriptional …

We present a surface-accelerated string method (SASM) to efficiently optimize low-
dimensional reaction pathways from the sampling performed with expensive quantum …

Los aptámeros son cadenas de oligonucleótidos de ARN o ADN elaborados sintéticamente,
que tienen la propiedad de unirse a moléculas objetivo con alta afinidad y especificidad …