The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

KCNQ1, also known as Kv7. 1, is a voltage-dependent K+ channel that regulates gastric
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …

Voltage-dependent ion channels underlie the propagation of action potentials and other
forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

For over 150 years Australia has exported bulk, undifferentiated, commodities such as wool,
wheat, meat and sugar to the UK and more recently to Japan, Korea, and the Middle East. It …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

The voltage-gated KCNQ1 (KvLQT1, Kv7. 1) potassium channel plays a crucial role in
shaping the cardiac action potential as well as in controlling the water and salt homeostasis …

Receptor-induced Ca2+ signals are key to the function of all cells and involve release of
Ca2+ from endoplasmic reticulum (ER) stores, triggering Ca2+ entry through plasma …

Rapidly activating and inactivating cardiac transient outward K+ currents, Ito, are expressed
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …