The human cytochrome P450 enzyme system metabolises a wide array of xenobiotics to
pharmacologically inactive metabolites, and occasionally, to toxicologically active …

The rate and extent of drug metabolism significantly influences drug effect. Enzyme
induction by increasing the metabolism of drugs may result in important drug interactions …

The cytochrome P450 enzyme family is one of the major drug metabolizing systems in man.
2. Factors such as age, gender, race, environment, and drug treatment may have …

The pharmacological effect of a drug is partly dependent upon its concentration at its site of
action, which in turn is determined by factors such as absorption, distribution and …

1. The principal methods used for the assessment of enzyme induction and enzyme
inhibition are measurement of the pharmacokinetics of a model compound (probe drug) …

The interaction between propranolol and warfarin was investigated in six healthy volunteers
using a low dose warfarin protocol and in New Zealand white rabbits. Warfarin concentration …

We investigated the effect of 4 days pretreatment with cimetidine (1.2 g daily) and ranitidine
(0.3 g daily) on tolbutamide disposition in an open randomised, cross-over study design …

Background and Purpose Classical pharmacological bioassays generally use observed
effects from a concentration series, at a single equilibrium time point to construct a …

There is evidence, from human and animal studies, that drug‐metabolising enzymes exist in
multiple forms, the individual enzymes having selective, but not specific, substrate …

The cannabinoid type 1 receptor (CB1) is among the most abundant G-protein-coupled
receptors (GPCRs) in the central nervous system (CNS). CB1 plays a vital role in CNS …