[HTML][HTML] Molecular mechanisms of antiproliferative effects of natural chalcones

R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …

[HTML][HTML] Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges

A Kumar, B BharathwajChetty, MK Manickasamy… - Pharmacological …, 2024 - Elsevier
Cancer has become a burgeoning global healthcare concern marked by its exponential
growth and significant economic ramifications. Though advancements in the treatment …

Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-κB system

B Yang, D Zhang, J Qian, Y Cheng - Molecular and Cellular Biochemistry, 2020 - Springer
Chelerythrine is a natural benzo [c] phenanthridine alkaloid found in many herbs and
displays a wide range of antitumor activities. Here, the present study tested their effects on …

[HTML][HTML] Reaction kinetics of aspalathin degradation and flavanone isomer formation in aqueous model solutions: effect of temperature, pH and metal chelators

D de Beer, C Human, M van der Rijst… - Food Research …, 2023 - Elsevier
The poor stability of aspalathin in aqueous solutions is a major challenge in delivering a
shelf-stable ready-to-drink (RTD) green rooibos iced tea. The kinetics of aspalathin …

Green rooibos extract attenuates high glucose induced oxidative stress in a human derived (HepG2) liver cell line

NS Abdul, JL Marnewick - South African Journal of Botany, 2022 - Elsevier
The exposure of hepatocytes to high concentrations of glucose results in a glucotoxic
environment and ensuing hepatocellular injury, often due to oxidative stress. The popularly …

Pentagalloylglucose suppresses the growth and migration of human nasopharyngeal cancer cells via the GSK3β/β-catenin pathway in vitro and in vivo

CW Fan, J Tang, JC Jiang, MM Zhou, MS Li, HS Wang - Phytomedicine, 2022 - Elsevier
Background Nasopharyngeal carcinoma (NPC) is a type of malignant squamous cell tumour
originating from the nasopharynx epithelium. Pentagalloylglucose (PGG) is a natural …

[HTML][HTML] Pyrogallol from Spirogyra neglecta Inhibits Proliferation and Promotes Apoptosis in Castration-Resistant Prostate Cancer Cells via Modulating Akt/GSK-3β/β …

P Arjsri, S Mapoung, W Semmarath… - International Journal of …, 2023 - mdpi.com
Castration-resistant prostate cancer (CRPC) is an advanced form of prostate cancer
associated with poor survival rates. The high proliferation and metastasis rates have made …

[HTML][HTML] Aspalathus linearis suppresses cell survival and proliferation of enzalutamide-resistant prostate cancer cells via inhibition of c-Myc and stability of androgen …

BJ Wang, SH Huang, CL Kao, CJF Muller, YP Wang… - Plos one, 2022 - journals.plos.org
Enzalutamide, a nonsteroidal antiandrogen, significantly prolonged the survival of patients
with metastatic castration-resistant prostate cancer (CRPC). However, patients receiving …

Aspalathin: a rare dietary dihydrochalcone from Aspalathus linearis (rooibos tea)

SK Chaudhary, M Sandasi, F Makolo… - Phytochemistry …, 2021 - Springer
Abstract Aspalathin (2′, 3, 4, 4′, 6′-pentahydroxy-3′-C-β-D-
glucopyranosyldihydrochalcone) is a natural C-linked glucosyl dihydrochalcone present in …

Differential cytotoxicity of rooibos and green tea extracts against primary rat hepatocytes and human liver and colon cancer cells–causal role of major flavonoids

S Samodien, M Kock, E Joubert… - Nutrition and …, 2021 - Taylor & Francis
Differential anti-proliferative and pro-apoptotic effects of aqueous extracts of green rooibos
(Rg; Aspalathus linearis) and green tea (GT; Camellia sinensis) and an aspalathin-enriched …