A review of natural products and small‐molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways …

A Pasdaran, ID Grice, A Hamedi - Drug Development Research, 2024 - Wiley Online Library
Abstract In 2021, the World Health Organization released the fifth edition of the central
nervous system (CNS) tumor classification. This classification uses histopathology and …

Structure and biological activity of Metarhizin C, a stereoisomer of BR-050 from Tolypocladium album RK17-F0007

T Nogawa, M Kawatani, A Okano, Y Futamura… - The Journal of …, 2019 - nature.com
Metarhizin C, a stereoisomer of BR-050 was isolated from a fungus Tolypocladium album
RK17-F0007 through a screening program to search for new antitumor compounds. A …

Грибы рода Colletotrichum как продуценты биологически активных соединений и биогербицидов

ЕВ Полуэктова, АО Берестецкий - Микология и фитопатология, 2018 - elibrary.ru
Обобщен материал о биологически активных метаболитах, образуемых грибами рода
Colletotrichum. Рассмотрены данные литературы о вторичных метаболитах грибов …

Secondary Metabolites of the Endophytic Fungus Chaetomium globosum Isolated From Coptis chinensis

JC Ji, PP Wei, XY Han, ZH Li, HL Ai… - Natural Product …, 2021 - journals.sagepub.com
A new steroid, chaetglotone (1), together with 3 known compounds (2-4), were isolated from
Chaetomium globosum, which is an endophytic fungus isolated from the root of Coptis …

Higginsianins D and E, Cytotoxic Diterpenoids Produced by Colletotrichum higginsianum

M Masi, A Cimmino, F Salzano, R Di Lecce… - Journal of natural …, 2020 - ACS Publications
Two new diterpenoids with tetrasubstituted 3-oxodihydrofuran substituents, named
higginsianins D (1) and E (2), were isolated from the mycelium of the fungus Colletotrichum …

[HTML][HTML] The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K …

YH Sheng, WJ Leu, CN Chen, JL Hsu, YT Liu, LC Hsu… - Molecules, 2020 - mdpi.com
Because conventional chemotherapy is not sufficiently effective against prostate cancer,
various examinations have been performed to identify anticancer activity of naturally …

Synthetic efforts towards the stereoselective synthesis of NF00659B1

DY Kwon, K Lee, H Park, MJ Kim, J Hong - Bioorganic & medicinal …, 2018 - Elsevier
NF00659B 1 is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer
activity. A stereoselective approach to the 2, 2-dimethyl oxepanol core of NF00659B 1 is …

Isolation and Characterization of Extracellular Vesicles from the Fungal Phytopathogen Colletotrichum higginsianum

BD Rutter, TTH Chu, KK Zajt, JF Dallery, RJ O'Connell… - bioRxiv, 2022 - biorxiv.org
Fungal phytopathogens secrete extracellular vesicles (EVs) associated with enzymes and
phytotoxic metabolites. While these vesicles are thought to promote infection, defining the …

Synthetic Biology-Based Natural Product Discovery

T Asai - New Tide of Natural Product Chemistry, 2023 - Springer
Natural products are historically one of the most important pharmaceutical sources for drug
development. In the post-genomic era, next generation sequencing analyses of …

Synthetic Biology-Based Natural Product Discovery Teigo Asai

T Asai - New Tide of Natural Product Chemistry, 2023 - books.google.com
Natural products are historically one of the most important pharmaceutical sources for drug
development. In the post-genomic era, next generation sequencing analyses of …