Dermal adipose tissue (also known as dermal white adipose tissue and herein referred to as
dWAT) has been the focus of much discussion in recent years. However, dWAT remains …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Specialized connective tissues, including bone and adipose tissues, control various
physiological activities, including mineral and energy homeostasis. However, the identity of …

The precursor cells for metabolically beneficial beige adipocytes can alternatively become
fibrogenic and contribute to adipose fibrosis. We found that cold exposure or β3-adrenergic …

Adult mesenchymal stem cells, including preadipocytes, possess a cellular sensory
organelle called the primary cilium. Ciliated preadipocytes abundantly populate perivascular …

Activated beige adipocytes have therapeutic potential due to their ability to improve glucose
and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether …

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only
serves as an energy reservoir, but also actively participates in metabolic homeostasis …

Obesity is a metabolic state generated by the expansion of adipose tissue. Adipose tissue
expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly …

Immune cells are vital constituents of the adipose microenvironment that influence both local
and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the …

Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis
from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis …