Increases in adipocyte volume and tissue mass due to obesity can result in inflammation,
further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like …

Mesenchymal stem/progenitor cells are essential for tissue development and repair
throughout life, but how they are maintained under chronic differentiation pressure is not …

Background Ageing is accompanied by sarcopenia and intramuscular fat (IMAT) infiltration.
In skeletal muscle, fat infiltration is a common feature in several myopathies and is …

Adipose precursor cells (APCs) exhibit regional variation in response to obesity, for unclear
reasons. Here, we reveal that HIFα-induced PDGFRβ signaling within murine white adipose …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

Single-cell sequencing technologies have revealed an unexpectedly broad repertoire of
cells required to mediate complex functions in multicellular organisms. Despite the multiple …

Single-cell RNA sequencing (scRNA-seq) has revealed that adult white adipose tissue
(WAT) harbors functionally diverse subpopulations of mesenchymal stromal cells that …

The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is
not fully understood. Here, we show that long-term treatment of T3, the active form of TH …

Chronic low-grade white adipose tissue (WAT) inflammation is a hallmark of metabolic
syndrome in obesity. Here, we demonstrate that a subpopulation of mouse WAT …

The important role of mitochondria in the regulation of white adipose tissue (WAT)
remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity …