Adipose tissue fibrosis: mechanisms, models, and importance
Increases in adipocyte volume and tissue mass due to obesity can result in inflammation,
further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like …
further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like …
Wnt signaling preserves progenitor cell multipotency during adipose tissue development
Z Yang Loureiro, S Joyce, T DeSouza… - Nature …, 2023 - nature.com
Mesenchymal stem/progenitor cells are essential for tissue development and repair
throughout life, but how they are maintained under chronic differentiation pressure is not …
throughout life, but how they are maintained under chronic differentiation pressure is not …
Single‐cell RNA sequencing and lipidomics reveal cell and lipid dynamics of fat infiltration in skeletal muscle
Z Xu, W You, W Chen, Y Zhou, Q Nong… - Journal of Cachexia …, 2021 - Wiley Online Library
Background Ageing is accompanied by sarcopenia and intramuscular fat (IMAT) infiltration.
In skeletal muscle, fat infiltration is a common feature in several myopathies and is …
In skeletal muscle, fat infiltration is a common feature in several myopathies and is …
[HTML][HTML] Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity
Adipose precursor cells (APCs) exhibit regional variation in response to obesity, for unclear
reasons. Here, we reveal that HIFα-induced PDGFRβ signaling within murine white adipose …
reasons. Here, we reveal that HIFα-induced PDGFRβ signaling within murine white adipose …
Lipodistrophy: a paradigm for understanding the consequences of “overloading” adipose tissue
K Lim, A Haider, C Adams, A Sleigh… - Physiological …, 2021 - journals.physiology.org
Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …
their rarity, tended to attract considerable medical attention because of the severity and …
Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells
Single-cell sequencing technologies have revealed an unexpectedly broad repertoire of
cells required to mediate complex functions in multicellular organisms. Despite the multiple …
cells required to mediate complex functions in multicellular organisms. Despite the multiple …
Multilayered omics reveal sex-and depot-dependent adipose progenitor cell heterogeneity
Single-cell RNA sequencing (scRNA-seq) has revealed that adult white adipose tissue
(WAT) harbors functionally diverse subpopulations of mesenchymal stromal cells that …
(WAT) harbors functionally diverse subpopulations of mesenchymal stromal cells that …
Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation
S Liu, S Shen, Y Yan, C Sun, Z Lu, H Feng, Y Ma… - Nature …, 2022 - nature.com
The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is
not fully understood. Here, we show that long-term treatment of T3, the active form of TH …
not fully understood. Here, we show that long-term treatment of T3, the active form of TH …
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity
Chronic low-grade white adipose tissue (WAT) inflammation is a hallmark of metabolic
syndrome in obesity. Here, we demonstrate that a subpopulation of mouse WAT …
syndrome in obesity. Here, we demonstrate that a subpopulation of mouse WAT …
Mitochondrial regulation and white adipose tissue homeostasis
The important role of mitochondria in the regulation of white adipose tissue (WAT)
remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity …
remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity …