Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response
to changes in physiological and environmental conditions. Here, we describe recent …

Abstract Single-cell RNA-Seq (scRNA-seq) is invaluable for studying biological systems.
Dimensionality reduction is a crucial step in interpreting the relation between cells in scRNA …

Adipose, or fat, tissue (AT) was once considered an inert tissue that primarily existed to store
lipids, and was not historically recognized as an important organ in the regulation and …

Single-cell RNA sequencing (scRNA-seq) enables molecular characterization of complex
biological tissues at high resolution. The requirement of single-cell extraction, however …

Obesity and its' associated metabolic diseases such as type 2 diabetes and cardiometabolic
disorders are significant health problems confronting many countries. A major driver for …

Cold exposure triggers neogenesis in classic interscapular brown adipose tissue (iBAT) that
involves activation of β1-adrenergic receptors, proliferation of PDGFRA+ adipose tissue …

Adipose tissue fibrosis is regulated by the chronic and progressive metabolic imbalance
caused by differences in caloric intake and energy expenditure. By exploring the cellular …

Kidney formation requires the coordinated growth of multiple cell types including the
collecting ducts, nephrons, vasculature and interstitium. There is a long-held belief that …

A central function of adipose tissue is in the management of systemic energy homeostasis
that is achieved through the co-ordinated regulation of energy storage and mobilization …

White and beige adipocytes in subcutaneous adipose tissue (SAT) and visceral adipose
tissue (VAT) are maintained by proliferation and differentiation of adipose progenitor cells …