The impact of single-cell genomics on adipose tissue research

A Deutsch, D Feng, JE Pessin, K Shinoda - International Journal of …, 2020 - mdpi.com
Adipose tissue is an important regulator of whole-body metabolism and energy
homeostasis. The unprecedented growth of obesity and metabolic disease worldwide has …

Reactivation of the epicardium at the origin of myocardial fibro-fatty infiltration during the atrial cardiomyopathy

N Suffee, T Moore-Morris, B Jagla, N Mougenot… - Circulation …, 2020 - Am Heart Assoc
Rationale: Fibro-fatty infiltration of subepicardial layers of the atrial wall has been shown to
contribute to the substrate of atrial fibrillation. Objective: Here, we examined if the …

Extracellular matrix remodeling facilitates obesity-associated cancer progression

M Kim, C Lee, J Park - Trends in cell biology, 2022 - cell.com
Obesity, a global public health concern, is an important risk factor for metabolic diseases
and several cancers. Fibro-inflammation in adipose tissues (ATs) is tightly associated with …

[PDF][PDF] Two faces of white adipose tissue with heterogeneous adipogenic progenitors

I Hwang, JB Kim - Diabetes & metabolism journal, 2019 - synapse.koreamed.org
Chronic energy surplus increases body fat, leading to obesity. Since obesity is closely
associated with most metabolic complications, pathophysiological roles of adipose tissue in …

Plasticity and heterogeneity of thermogenic adipose tissue

W Sun, S Modica, H Dong, C Wolfrum - Nature metabolism, 2021 - nature.com
The perception of adipose tissue, both in the scientific community and in the general
population, has changed dramatically in the past 20 years. While adipose tissue was …

Leptin in the regulation of the immunometabolism of adipose tissue-macrophages

L Monteiro, JAS Pereira, L Palhinha… - Journal of leukocyte …, 2019 - academic.oup.com
Obesity is a pandemic disease affecting around 15% of the global population. Obesity is a
major risk factor for other conditions, such as type 2 diabetes and cardiovascular diseases …

Cold-induced reprogramming of subcutaneous white adipose tissue assessed by single-cell and single-nucleus RNA sequencing

Q Liu, Q Long, J Zhao, W Wu, Z Lin, W Sun, P Gu… - Research, 2023 - spj.science.org
Adipose browning has demonstrated therapeutic potentials in several diseases. Here, by
conducting transcriptomic profiling at the single-cell and single-nucleus resolution, we …

Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice

Q Chen, SM Lai, S Xu, Y Tan, K Leong, D Liu… - EMBO …, 2021 - embopress.org
Tissue‐resident macrophages in white adipose tissue (WAT) dynamically adapt to the
metabolic changes of their microenvironment that are often induced by excess energy …

Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity

AK Ramirez, SN Dankel, B Rastegarpanah… - Nature …, 2020 - nature.com
White adipose tissue plays an important role in physiological homeostasis and metabolic
disease. Different fat depots have distinct metabolic and inflammatory profiles and are …

Estradiol cycling drives female obesogenic adipocyte hyperplasia

RM Saavedra-Peña, N Taylor, C Flannery… - Cell reports, 2023 - cell.com
White adipose tissue (WAT) distribution is sex dependent. Adipocyte hyperplasia contributes
to WAT distribution in mice driven by cues in the tissue microenvironment, with females …