The impact of single-cell genomics on adipose tissue research
Adipose tissue is an important regulator of whole-body metabolism and energy
homeostasis. The unprecedented growth of obesity and metabolic disease worldwide has …
homeostasis. The unprecedented growth of obesity and metabolic disease worldwide has …
Reactivation of the epicardium at the origin of myocardial fibro-fatty infiltration during the atrial cardiomyopathy
N Suffee, T Moore-Morris, B Jagla, N Mougenot… - Circulation …, 2020 - Am Heart Assoc
Rationale: Fibro-fatty infiltration of subepicardial layers of the atrial wall has been shown to
contribute to the substrate of atrial fibrillation. Objective: Here, we examined if the …
contribute to the substrate of atrial fibrillation. Objective: Here, we examined if the …
Extracellular matrix remodeling facilitates obesity-associated cancer progression
M Kim, C Lee, J Park - Trends in cell biology, 2022 - cell.com
Obesity, a global public health concern, is an important risk factor for metabolic diseases
and several cancers. Fibro-inflammation in adipose tissues (ATs) is tightly associated with …
and several cancers. Fibro-inflammation in adipose tissues (ATs) is tightly associated with …
[PDF][PDF] Two faces of white adipose tissue with heterogeneous adipogenic progenitors
Chronic energy surplus increases body fat, leading to obesity. Since obesity is closely
associated with most metabolic complications, pathophysiological roles of adipose tissue in …
associated with most metabolic complications, pathophysiological roles of adipose tissue in …
Plasticity and heterogeneity of thermogenic adipose tissue
The perception of adipose tissue, both in the scientific community and in the general
population, has changed dramatically in the past 20 years. While adipose tissue was …
population, has changed dramatically in the past 20 years. While adipose tissue was …
Leptin in the regulation of the immunometabolism of adipose tissue-macrophages
L Monteiro, JAS Pereira, L Palhinha… - Journal of leukocyte …, 2019 - academic.oup.com
Obesity is a pandemic disease affecting around 15% of the global population. Obesity is a
major risk factor for other conditions, such as type 2 diabetes and cardiovascular diseases …
major risk factor for other conditions, such as type 2 diabetes and cardiovascular diseases …
Cold-induced reprogramming of subcutaneous white adipose tissue assessed by single-cell and single-nucleus RNA sequencing
Q Liu, Q Long, J Zhao, W Wu, Z Lin, W Sun, P Gu… - Research, 2023 - spj.science.org
Adipose browning has demonstrated therapeutic potentials in several diseases. Here, by
conducting transcriptomic profiling at the single-cell and single-nucleus resolution, we …
conducting transcriptomic profiling at the single-cell and single-nucleus resolution, we …
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice
Q Chen, SM Lai, S Xu, Y Tan, K Leong, D Liu… - EMBO …, 2021 - embopress.org
Tissue‐resident macrophages in white adipose tissue (WAT) dynamically adapt to the
metabolic changes of their microenvironment that are often induced by excess energy …
metabolic changes of their microenvironment that are often induced by excess energy …
Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity
AK Ramirez, SN Dankel, B Rastegarpanah… - Nature …, 2020 - nature.com
White adipose tissue plays an important role in physiological homeostasis and metabolic
disease. Different fat depots have distinct metabolic and inflammatory profiles and are …
disease. Different fat depots have distinct metabolic and inflammatory profiles and are …
Estradiol cycling drives female obesogenic adipocyte hyperplasia
RM Saavedra-Peña, N Taylor, C Flannery… - Cell reports, 2023 - cell.com
White adipose tissue (WAT) distribution is sex dependent. Adipocyte hyperplasia contributes
to WAT distribution in mice driven by cues in the tissue microenvironment, with females …
to WAT distribution in mice driven by cues in the tissue microenvironment, with females …