Obesity, inflammation, and cancer

T Deng, CJ Lyon, S Bergin, MA Caligiuri… - Annual Review of …, 2016 - annualreviews.org
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including cancer, and is increasingly recognized as a growing cause of preventable cancer …

Obesity and cancer—mechanisms underlying tumour progression and recurrence

J Park, TS Morley, M Kim, DJ Clegg… - Nature Reviews …, 2014 - nature.com
Over the past several years, the field of cancer research has directed increased interest
towards subsets of obesity-associated tumours, which include mammary, renal …

[PDF][PDF] Obesity and cancer: the oil that feeds the flame

J Font-Burgada, B Sun, M Karin - Cell metabolism, 2016 - cell.com
Although discussion of the obesity epidemic had become a cocktail party cliché, its impact
on public health cannot be dismissed. In the past decade, cancer had joined the list of …

Wnt signaling in ovarian cancer stemness, EMT, and therapy resistance

M Teeuwssen, R Fodde - Journal of clinical medicine, 2019 - mdpi.com
Ovarian cancers represent the deadliest among gynecologic malignancies and are
characterized by a hierarchical structure with cancer stem cells (CSCs) endowed with self …

Obesity and colorectal cancer

M Bardou, AN Barkun, M Martel - Gut, 2013 - gut.bmj.com
Excess body weight, as defined by the body mass index (BMI), has been associated with
several diseases and includes subjects who are overweight (BMI≥ 25–29.9 kg/m2) or …

[HTML][HTML] Epidemiological transition of colorectal cancer in developing countries: environmental factors, molecular pathways, and opportunities for prevention

F Bishehsari, M Mahdavinia, M Vacca… - World journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the leading causes of cancer and cancer-related mortality
worldwide. The disease has been traditionally a major health problem in industrial countries …

Obesity, type 2 diabetes, and cancer: the insulin and IGF connection

DH Cohen, D LeRoith - Endocrine-related cancer, 2012 - erc.bioscientifica.com
Epidemiological studies suggest a positive association between obesity and type 2 diabetes
mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance …

[HTML][HTML] The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

MN Duong, A Geneste, F Fallone, X Li, C Dumontet… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Growing evidence has raised the important roles of adipocytes as an active player in the
tumor microenvironment. In many tumors adipocytes are in close contact with cancer cells …

Linking obesity with colorectal cancer: epidemiology and mechanistic insights

P Ye, Y Xi, Z Huang, P Xu - Cancers, 2020 - mdpi.com
The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades.
More than 650 million obese and 2 billion overweight individuals are currently living in the …

[HTML][HTML] The link between the metabolic syndrome and cancer

S Braun, K Bitton-Worms, D LeRoith - International journal of …, 2011 - ncbi.nlm.nih.gov
Since the incidence of the metabolic syndrome is on the rise in the western world, its
coherence to cancer is becoming more apparent. In this review we discuss the different …