SOD1 is the major superoxide dismutase responsible for catalyzing dismutation of
superoxide to hydrogen peroxide and molecular oxygen. It is well known as an essential …

Mitochondria regulate cellular bioenergetics and apoptosis and have been implicated in
aging. However, it remains unclear whether age‐related loss of muscle mass, known as …

Simple Summary Chemotherapy resistance is a common occurrence during cancer
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …

Background: A common phenotype associated with heart failure is the development of
cardiac hypertrophy. Cardiac hypertrophy occurs in response to stress, such as …

Significance: Mitochondria are fundamental to the life and proper functioning of cells. These
organelles play a key role in energy production, in maintaining homeostatic levels of second …

Chemotherapy is the major choice for the cancer treatment of early and advanced stages.
However, intrinsic or acquired drug resistance significantly restricts the clinical efficacy of …

Cancer cells display abnormal metabolic activity as a result of activated oncogenes and loss
of tumor suppressor genes. The Warburg Effect is a common metabolic feature of cancer that …

The eukaryotic translation initiation factor 5A (eIF5A) is an evolutionarily conserved protein
that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or …

Respiring mitochondria produce H 2 O 2 continuously. When production exceeds
scavenging, H 2 O 2 emission occurs, endangering cell functions. The mitochondrial …

Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …