Motivation It is a challenging task to discover personalized driver genes that provide crucial
information on disease risk and drug sensitivity for individual patients. However, few …

Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of
energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone …

Normal cells require adhesion to extracellular matrix for survival. Cell detachment causes a
drastic increase in reactive oxygen species (ROS) that promotes anoikis. In the present …

In healthy kidneys, interstitial fibroblasts are responsible for the maintenance of renal
architecture. Progressive interstitial fibrosis is thought to be a common pathway for chronic …

Reactive oxygen species (ROS) have been proposed as one of the main causes of the
impairment of fish spermatozoa integrity and functionality during cryopreservation. The high …

Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by impaired
clearance of pulmonary bacteria. Objectives: The effect of COPD on alveolar macrophage …

Aims Lectin-like ox-LDL scavenger receptor-1 (LOX-1) and mitochondrial DNA (mtDNA)
damage play a key role in a variety of cardiovascular diseases, including atherosclerosis …

Cisplatin is one of the most potent and widely used chemotherapeutic agent in the treatment
of several solid tumors, despite the high toxicity and the frequent relapse of patients due to …

Considering that the aberrant levels of hypochlorous acid (HClO) is closely related to the
occurrence and development of various diseases, many efforts have been made to develop …

Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan
(HA), were used to prepare membranes with the aim to protect and to enhance the healing …