The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …

Polycystic ovary syndrome (PCOS), one of the most common endocrine diseases that
causes infertility in reproductive women, is characterized by hyperandrogenemia, chronic …

Advanced maternal age (AMA;> 35 year) is associated with a decline in both ovarian
reserve and oocyte competence. At present, no remedies are available to counteract the …

Across the Western World there is an increasing trend to postpone childbearing.
Consequently, the negative influence of age on oocyte quality may lead to a difficulty in …

As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …

Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …

Ovarian aging leads to a decrease in the quantity and quality of oocytes. Aged oocytes have
significantly reduced amounts of mitochondria, the energy factories of cells, leading to lower …

Mitochondria are highly dynamic organelles and their distribution, structure and activity
affect a wide range of cellular functions. Mitochondrial membrane potential (∆ Ψm) is an …