Fibrosis is the final common pathway of inflammatory diseases in various organs. The
inflammasomes play an important role in the progression of fibrosis as innate immune …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Objective Acute kidney injury (AKI) is a common complication of acute liver failure (ALF).
Pyroptosis is a necrosis type related to inflammation. This study aimed to investigate the role …

AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under
these conditions, renal tubular cell death may occur by regulated necrosis (RN) or …

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As
the underlying mechanisms of this inflammation remain poorly defined, specific therapies …

Kidney injury implies danger signaling and a response by the immune system. The
inflammasome is a central danger recognition platform that triggers local and systemic …

Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

Increasing incidences of obesity and diabetes have made diabetic kidney disease (DKD) the
leading cause of chronic kidney disease and end-stage renal disease worldwide. Despite …

Primary/secondary hyperoxalurias involve nephrocalcinosis-related chronic kidney disease
(CKD) leading to end-stage kidney disease. Mechanistically, intrarenal calcium oxalate …

Chronic kidney disease affects approximately 14.3% of people worldwide. Tubulointerstitial
fibrosis is the final stage of almost all progressive CKD. To date, the pathogenesis of renal …