Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and persistent
inflammation in circulatory and renal tissues is an important pathophysiological basis for DN …

The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney
fibrosis. However, it is unknown whether PGC-1α, a key mitochondrial biogenesis regulator …

A critical component of innate immune response to infection and tissue damage is the
NACHT, LRR, and PYD domains–containing protein 3 (NLRP3) inflammasome, and this …

IL-1β-secreting nucleotide-binding oligomerization domain protein 3 (NLRP3)
inflammasomes play a pivotal role in triggering innate immune responses in metabolic …

Ketone bodies including β-hydroxybutyrate (β-OHB) have been shown to protect against
ischemic tissue injury when present at low concentrations. We evaluated the impact of β …

Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs)
are families of pattern recognition receptors that, together with inflammasomes, sense and …

Background Diabetic myopathy involves hyperglycaemia and inflammation that causes
skeletal muscle dysfunction; however, the potential cellular mechanisms that occur between …

NLRP3 inflammasome is an intracellular protein complex that initiates cellular injury via
assembly of NLRP3, ASC and caspase-1 in response to microbial infection and sterile …

Background Diabetic nephropathy (DN) is a lethal diabetic microvascular complication
characterized by chronic low-grade inflammation. The NOD-like receptor pyrin domain …

The NLRP3 inflammasome is a cytosolic multiprotein caspase-activating complex platform
involved in innate immunity required for the maturation and release of interleukin (IL)-1β and …