The findings reviewed in this article expand our understanding of the relevance of elevated
plasma oxalate levels leading to inflammasome activation. We propose that inhibiting …

Background Nephrolithiasis is a common urinary disease with a high recurrence rate of
secondary stone formation. Several mechanisms are involved in the onset and recurrence of …

Inflammasomes are multiprotein platforms responsible for the release of pro-inflammatory
cytokines interleukin (IL)-1β and IL-18. Mouse studies have identified inflammasome …

Background: The entity of crystal nephropathies encompasses a spectrum of different kidney
injuries induced by crystal-formed intrinsic minerals, metabolites, and proteins or extrinsic …

Diabetes mellitus is an increasingly prevalent disease around the globe. The epidemic of
diabetes mellitus and its complications pretenses the foremost health threat globally …

Folic acid (FA)-induced renal tubule damage, which is characterized by extensive
inflammation, is a common model of acute kidney injury (AKI). Pyroptosis, a pro …

Acute kidney injury is a common clinical condition associated with increased morbidity and
mortality. It is essential to find effective drugs with low side effects in the treatment of acute …

Nucleotide-binding oligomerization domain-like receptors (NLRs), including NLRAs, NLRBs
(also known as NAIPs), NLRCs, and NLRPs, are a major subfamily of pattern recognition …

Progressive fibrosis in chronic kidney disease (CKD) is the well-recognized cause leading to
the progressive loss of renal function. Emerging evidence indicated a pathogenic role of the …

Curcumin, a traditional Chinese medicine extracted from natural plant rhizomes, has
become a candidate drug for the treatment of different diseases due to its anti-inflammatory …