Cellular and physiological mechanisms of halogenated and organophosphorus flame retardant toxicity

L Khani, L Martin, Ł Pułaski - Science of the Total Environment, 2023 - Elsevier
Flame retardants (FRs) are chemical substances used to inhibit the spread of fire in
numerous industrial applications, and their abundance in modern manufactured products in …

[HTML][HTML] Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge

A Rodríguez-Carrillo, V Mustieles… - International Journal of …, 2023 - Elsevier
Human biomonitoring (HBM) studies have highlighted widespread daily exposure to
environmental chemicals. Some of these are suspected to contribute to adverse health …

EDC-predictor: a novel strategy for prediction of endocrine-disrupting chemicals by integrating pharmacological and toxicological profiles

Z Yu, Z Wu, M Zhou, K Cao, W Li, G Liu… - … Science & Technology, 2023 - ACS Publications
Identification of endocrine-disrupting chemicals (EDCs) is crucial in the reduction of human
health risks. However, it is hard to do so because of the complex mechanisms of the EDCs …

The effects of endocrine‐disrupting chemicals on ovarian‐and ovulation‐related fertility outcomes

KL Land, FG Miller, AC Fugate… - Molecular …, 2022 - Wiley Online Library
Exposure to endocrine‐disrupting chemicals (EDCs) is unavoidable, which represents a
public health concern given the ability of EDCs to target the ovary. However, there is a large …

Chlorinated organophosphorus flame retardants-induced mitochondrial abnormalities and the correlation with progesterone production in mLTC-1 cells

Y Feng, X Cui, J Yin, B Shao - Food and Chemical Toxicology, 2022 - Elsevier
Environmental monitoring data have indicated that three chlorinated organophosphorus
flame retardants (Cl-OPFRs), including tris (2-chloroethyl)-phosphate (TCEP), tris (2 …

Replacement flame-retardant 2-ethylhexyldiphenyl phosphate (EHDPP) disrupts hepatic lipidome: evidence from human 3D hepatospheroid cell culture

CK Negi, D Gadara, J Kohoutek, L Bajard… - Environmental …, 2023 - ACS Publications
The present study aims to evaluate the effects of repeated exposure to 2-ethylhexyldiphenyl
phosphate (EHDPP) on human liver cells. In vitro three-dimensional (3D) hepatospheroid …

Accumulation of organophosphorus pollutants in adipose tissue of obese women-metabolic alterations

S Sousa, D Rede, VC Fernandes, D Pestana… - Environmental …, 2023 - Elsevier
Organophosphorus pesticides (OPPs) and organophosphate esters (OPEs) are
organophosphorus compounds created as substitutes for persistent environmental …

A comparative study on endocrine disrupting effects of leachates from virgin and aged plastics under simulated media in marine medaka larvae (Oryzias melastigma)

SQ Qiu, GY Huang, XP Li, DQ Lei, CS Wang… - Journal of Hazardous …, 2023 - Elsevier
Marine plastic pollution has garnered substantial attention, but the potential endocrine
disrupting effects of plastic leachates in marine organisms remain unclear. In this study, the …

[HTML][HTML] Comparison of the mechanisms of estrogen disrupting effects between triphenyl phosphate (TPhP) and tris (1, 3-dichloro-2-propyl) phosphate (TDCIPP)

X Ji, N Li, M Ma, X Li, K Zhu, K Rao, Z Wang… - Ecotoxicology and …, 2022 - Elsevier
As the typical aryl-organophosphate flame retardants (OPFRs), triphenyl phosphate (TPhP)
and tris (1, 3-dichloro-2-propyl) phosphate (TDCIPP) were reported to be estrogen …

The European regulatory strategy for flame retardants–The right direction but still a risk of getting lost

J de Boer, S Harrad, M Sharkey - Chemosphere, 2023 - Elsevier
Flame retardants (FRs) are a major group of chemicals used to protect against fast
developing fires and comply with fire regulations. Many of them have a negative impact on …