The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases
DEM Maessen, CDA Stehouwer… - Clinical …, 2015 - portlandpress.com
The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …
Recent updates in anti-glycation strategies: selection of natural products and lactic acid bacteria as potential inhibitors based on the multi-pathway anti-glycation …
K Yue, B Mao, X Tang, Q Zhang, J Zhao… - Critical Reviews in …, 2023 - Taylor & Francis
The prevalence of high-sugar diets and unhealthy habits exacerbates the production of
advanced glycation end products (AGEs) in the body. When AGEs excessively accumulate …
advanced glycation end products (AGEs) in the body. When AGEs excessively accumulate …
MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy
X Bai, J Geng, Z Zhou, J Tian, X Li - Scientific reports, 2016 - nature.com
Abstract MicroRNA-130b (miR-130b) downregulation has been identified in diabetes, but
the role and mechanisms for miR-130b in mediating renal tubulointerstitial fibrosis in …
the role and mechanisms for miR-130b in mediating renal tubulointerstitial fibrosis in …
Methylglyoxal in metabolic disorders: facts, myths, and promises
P Matafome, T Rodrigues, C Sena… - Medicinal research …, 2017 - Wiley Online Library
Glucose and fructose metabolism originates the highly reactive byproduct methylglyoxal
(MG), which is a strong precursor of advanced glycation end products (AGE). The MG has …
(MG), which is a strong precursor of advanced glycation end products (AGE). The MG has …
A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and …
Liver fibrosis is a common chronic hepatic disease. This study was done to examine the
effect of pyridoxamine against thioacetamide-induced hepatic fibrosis. Animals were divided …
effect of pyridoxamine against thioacetamide-induced hepatic fibrosis. Animals were divided …
Distinct impact of natural sugars from fruit juices and added sugars on caloric intake, body weight, glycaemia, oxidative stress and glycation in diabetic rats
T Monteiro-Alfredo, B Caramelo, D Arbeláez, A Amaro… - Nutrients, 2021 - mdpi.com
Although fruit juices are a natural source of sugars, there is a controversy whether their
sugar content has similar harmful effects as beverages' added-sugars. We aimed to study …
sugar content has similar harmful effects as beverages' added-sugars. We aimed to study …
Potential of vasoprotectives to inhibit non-enzymatic protein glycation, and reactive carbonyl and oxygen species uptake
K Bednarska, I Fecka - International Journal of Molecular Sciences, 2021 - mdpi.com
Reactive carbonyl species (RCS) such as methylglyoxal (MGO) or glyoxal (GO) are the main
precursors of the formation of advanced glycation end products (AGEs). AGEs are a major …
precursors of the formation of advanced glycation end products (AGEs). AGEs are a major …
Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance
T Rodrigues, P Matafome, J Sereno, J Almeida… - Scientific reports, 2017 - nature.com
Microvascular dysfunction has been suggested to trigger adipose tissue dysfunction in
obesity. This study investigates the hypothesis that glycation impairs microvascular …
obesity. This study investigates the hypothesis that glycation impairs microvascular …
Methylglyoxal Impairs Insulin Secretion of Pancreatic β‐Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of …
J Bo, S Xie, Y Guo, C Zhang, Y Guan… - Journal of diabetes …, 2016 - Wiley Online Library
Methylglyoxal (MG) is a highly reactive glucose metabolic intermediate and a major
precursor of advanced glycation end products. MG level is elevated in hyperglycemic …
precursor of advanced glycation end products. MG level is elevated in hyperglycemic …
Investigation of the Phytochemical Composition, Antioxidant Activity, and Methylglyoxal Trapping Effect of Galega officinalis L. Herb In Vitro
Galega officinalis L. has been known for centuries as an herbal medicine used to alleviate
the symptoms of diabetes, but its comprehensive chemical composition and …
the symptoms of diabetes, but its comprehensive chemical composition and …