Abstract Calcium (Ca 2+) and reactive oxygen species (ROS) are versatile signaling
molecules coordinating physiological and pathophysiological processes. While channels …

There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because
contraction is mainly driven by Ca released from the sarcoplasmic reticulum (SR), this …

Flecainide, a cardiac class 1C blocker of the surface membrane sodium channel (NaV1. 5),
has also been reported to reduce cardiac ryanodine receptor (RyR2)-mediated …

Aims In ventricular myocytes from humans and large mammals, the transverse and axial
tubular system (TATS) network is less extensive than in rodents with consequently a greater …

Cardiac ryanodine receptors (RyR2) release the Ca2+ from intracellular stores that is
essential for cardiac myocyte contraction. The ion channel opening is tightly regulated by …

Excitation-contraction coupling links excitation of the sarcolemmal surface membrane to
mechanical contraction. In the heart this link is established via a Ca 2+-induced Ca 2+ …