[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

[HTML][HTML] Metabolic-associated fatty liver disease (MAFLD): a multi-systemic disease beyond the liver

E Kaya, Y Yilmaz - Journal of clinical and translational hepatology, 2022 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a multisystemic clinical condition that presents
with a wide spectrum of extrahepatic manifestations, such as obesity, type 2 diabetes …

[HTML][HTML] TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

RY Li, Q Qin, HC Yang, YY Wang, YX Mi, YS Yin… - Molecular …, 2022 - Springer
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

[HTML][HTML] Cognitive dysfunction in non-alcoholic fatty liver disease—current knowledge, mechanisms and perspectives

K Kjærgaard, ACD Mikkelsen, CW Wernberg… - Journal of Clinical …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the hepatic component of the
metabolic syndrome and now seemingly affects one-fourth of the world population. Features …

Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease

Y Luo, H Lin - Immunity, Inflammation and Disease, 2021 - Wiley Online Library
Low‐level of chronic inflammation activation is characteristic of obesity. Nonalcoholic fatty
liver disease (NAFLD) is closely linked to obesity and is an emerging health problem, it …

[HTML][HTML] Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation

SY Cheon, J Song - Cell & Bioscience, 2022 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple
pathologies. The progression of dementia with NAFLD may be affected by various risk …

[HTML][HTML] Depression and cognitive impairment—extrahepatic manifestations of NAFLD and NASH

M Colognesi, D Gabbia, S De Martin - Biomedicines, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) and its complication non-alcoholic steatohepatitis
(NASH) are important causes of liver disease worldwide. Recently, a significant association …

[HTML][HTML] An integrated view on vascular dysfunction in Alzheimer's disease

J Klohs - Neurodegenerative Diseases, 2020 - karger.com
Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's
disease (AD). It is believed to contribute additively to the cognitive impairment and to lower …

Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation

J Li, L Li, DM Guo, SY Li, YX Zeng, CH Liu, RU Fu… - Clinica Chimica …, 2020 - Elsevier
Hypertriglyceridemia is a risk factor for a series of diseases, such as cardiovascular disease
(CVD), diabetes and nonalcoholic fatty liver disease (NAFLD). Angiopoietin-like proteins …

[HTML][HTML] The potential role of inflammation in modulating endogenous hippocampal neurogenesis after spinal cord injury

A Sefiani, CG Geoffroy - Frontiers in Neuroscience, 2021 - frontiersin.org
Currently there are approximately 291,000 people suffering from a spinal cord injury (SCI) in
the United States. SCI is associated with traumatic changes in mobility and neuralgia, as …