Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Clustered DNA lesions, also called Multiply Damaged Sites, is the hallmark of ionizing
radiation. It is defined as the combination of two or more lesions, comprising strand breaks …

Biological responses to ionizing radiation (IR) have been studied for many years, generally
showing the dependence of these responses on the quality of radiation, ie, the radiation …

Radiation mutation breeding has been used for nearly 100 years and has successfully
improved crops by increasing genetic variation. Global food production is facing a series of …

Compared to conventional photon-based external beam radiation (PhXRT), carbon ion
radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and …

Recent epidemiology studies highlighted the detrimental health effects of exposure to low
dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown …

Radiotherapy (ionising radiation; IR) is utilised in the treatment of~ 50% of all human
cancers, and where the therapeutic effect is largely achieved through DNA damage …

Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton
beams are used to precisely deliver the dose to the tumor target but is generally considered …

Photons, such as X-or γ-rays, induce DNA damage (distributed throughout the nucleus) as a
result of low-density energy deposition. In contrast, particle irradiation with high linear …

Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …