Behçet's disease (BD) is a chronic vasculitis characterized by systemic immune aberrations.
However, a comprehensive understanding of immune disturbances in BD and how they …

Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and
maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2, 3-dioxygenase 1 …

Recently emerged mass cytometry (cytometry by time‐of‐flight [CyTOF]) technology permits
the identification and quantification of inherently diverse cellular systems, and the …

Despite having disease-specific pathologic features and symptoms, neurodegenerative
diseases share common mechanisms, such as excitotoxicity, neuroinflammation, and …

Stress-induced disturbances of brain homeostasis and neuroinflammation have been
implicated in the pathophysiology of mood disorders. In major depressive disorder (MDD) …

Background NLRP3‐driven inflammatory responses by circulating and lung‐resident
monocytes are critical drivers of asthma pathogenesis. Autophagy restrains NLRP3‐induced …

Myeloid cells are suggested as an important player in Alzheimer´ s disease (AD). However,
its continuum of phenotypic and functional changes across different body compartments and …

One of the biggest challenges in managing multiple sclerosis is the heterogeneity of clinical
manifestations and progression trajectories. It still remains to be elucidated whether this …

Myeloid cells contribute to inflammation and demyelination in the early stages of multiple
sclerosis (MS), but it is still unclear to what extent these cells are involved in active lesion …

Summary Background Regulatory T cells (Tregs) can alleviate the development of
autoimmune and inflammatory diseases, thereby proposing their role as a new therapeutic …