This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild
to severe malaria infection. Given the therapeutic significance of AS and the necessity of …

Introduction: Chemotherapy of malaria has become a rapidly changing field. Less than two
decades ago, treatment regimens were increasingly bound to fail due to emerging drug …

Acute lung injury (ALI) is a severe health issue with significant morbidity and mortality.
Artemisinin is used for the treatment of fever and malaria in clinical practice …

Severe malaria in pregnancy is a large contributor to maternal morbidity and mortality.
Intravenous quinine has traditionally been the treatment drug of choice for severe malaria in …

Over the past 10 years, the available evidence on the treatment of malaria during pregnancy
has increased substantially. Owing to their relative ease of use, good sensitivity and …

Use of pharmacotherapy during pregnancy is common and increasing. Physiologic changes
during pregnancy may significantly alter the overall systemic drug exposure, necessitating …

The prevention and treatment of malaria is heavily dependent on antimalarial drugs.
However, beginning with the emergence of chloroquine (CQ)-resistant Plasmodium …

Introduction: Malaria in pregnancy and postpartum cause maternal mortality and adverse
fetal outcomes. Efficacious and safe antimalarials are needed to treat and prevent such …

Dihydroartemisinin-piperaquine is a fixed-dose artemisinin-based combination treatment.
Some antimalarials have altered pharmacokinetics in pregnancy. Pregnant women in the …