Neuroendocrine neoplasia of the gastrointestinal tract revisited: towards precision medicine

G Rindi, B Wiedenmann - Nature Reviews Endocrinology, 2020 - nature.com
Over the past 5 years, a number of notable research advances have been made in the field
of neuroendocrine cancer, specifically with regard to neuroendocrine cancer of the …

[HTML][HTML] The evolution of PRRT for the treatment of neuroendocrine tumors; What comes next?

PE Harris, K Zhernosekov - Frontiers in Endocrinology, 2022 - frontiersin.org
Lu-177 has been developed for the treatment of patients with peptide receptor radionuclide
therapy (PRRT). A second generation pure no-carrier-added Lu-177 has a high specific …

[HTML][HTML] Gastrinoma

RT Jensen, T Ito - Endotext [Internet], 2023 - ncbi.nlm.nih.gov
Gastrinomas are neuroendocrine neoplasms (NENs), that occur primarily in the duodenum
and pancreas, which ectopically secrete gastrin, resulting in the Zollinger-Ellison syndrome …

[HTML][HTML] Immunological role and prognostic value of somatostatin receptor family members in colon adenocarcinoma

X Yu, X Yang, H Nie, W Jiang, X He… - Frontiers in Pharmacology, 2023 - frontiersin.org
Colon adenocarcinoma (COAD) is among the most prevalent cancers worldwide, ranking as
the third most prevalent malignancy in incidence and mortality. The somatostatin receptor …

[HTML][HTML] Predictive factors for resistant disease with medical/radiologic/liver-directed anti-tumor treatments in patients with advanced pancreatic neuroendocrine …

L Lee, I Ramos-Alvarez, RT Jensen - Cancers, 2022 - mdpi.com
Simple Summary Tumor resistance, both primary and acquired, is leading to increased
complexity in the nonsurgical treatment of patients with advanced panNENs, which would be …

Clinical Characteristics and Management of Functional Pancreatic Neuroendocrine Neoplasms: A Single Institution 20‐Year Experience with 286 Patients

Y Qu, H Li, X Wang, Y Chen, Q Guo… - International journal …, 2020 - Wiley Online Library
Background. Functional pancreatic neuroendocrine neoplasms (PanNENs) are very rare
disorders but have complex spectrum, including insulinoma, gastrinoma, glucagonoma …

Combined use of 177Lu‐DOTATATE peptide receptor radionuclide therapy and fluzoparib for treatment of well‐differentiated neuroendocrine tumors: A preclinical …

J Fu, F Qiu, CR Stolniceanu, F Yu… - Journal of …, 2022 - Wiley Online Library
Peptide receptor radionuclide therapy (177Lu‐DOTATATE) causes DNA strand breaks and
has been validated for well‐differentiated neuroendocrine tumor treatment. Poly‐(ADP …

[HTML][HTML] ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an …

J Chen, M Ye, J Bai, Z Gong, L Yan, D Gu, C Hu… - Journal of Translational …, 2023 - Springer
The process of post-transcriptional regulation has been recognized to be significantly
impacted by the presence of N 6-methyladenosine (m6A) modification. As an m6A …

The overriding role of surgery and tumor grade for long‐term survival in patients with gastroenteropancreatic neuroendocrine neoplasms: A population‐based cohort …

JA Søreide, JT Kvaløy, D Lea, OM Sandvik… - Cancer …, 2022 - Wiley Online Library
Background Gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) comprise a
heterogeneous disease group. Factors that affect long‐term survival remain uncertain …

[HTML][HTML] Clinical and molecular characteristics of rare malignant tumors of colon and rectum

A Ottaiano, M Santorsola, F Perri, U Pace, B Marra… - Biology, 2022 - mdpi.com
Simple Summary Tumors of colon and rectum other than adenocarcinomas represent a
neglected issue from clinical and laboratory points of view because of their rarity. In this …