Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Though chronic autoimmune disorders such as rheumatoid arthritis or systemic lupus
erythematosus affect a significant percentage of the human population and strongly diminish …

Apheresis has been recognized both economically and therapeuticallyas a novel approach
for the treatment of inflammatory diseases, and certain others, which respond poorly to drug …

Active ulcerative colitis (UC) is characterized by activation and infiltration of granulocytes
and monocytes/macrophages into the colonic mucosa. The infiltrated leukocytes can cause …

BACKGROUND & AIMS: Activated granulocytes and monocytes/macrophages are
implicated in the pathogenesis of ulcerative colitis. Open-label studies and clinical …

Background & Aims: Active ulcerative colitis (UC) is characterized by infiltration of activated
granulocytes and monocytes/macrophages (GM) within the large bowel mucosa. GM are …

Our aim was to understand the mechanism of immunological changes associated with the
use of an adsorptive-type extracorporeal device (Adacolumn) that has been developed for …

Corticosteroid therapy of ulcerative colitis (UC) is associated with frequent adverse side
effects and poor quality of life. Recently, adsorptive granulocyte and monocyte/macrophage …

Background/Aim: Active ulcerative colitis (UC) is often associated with increased peripheral
granulocytes and monocytes/macrophages which show activation behavior and prolonged …

Granulocyte and monocyte adsorptive apheresis (GMA) using a column filled with cellulose
acetate (CA) beads (carriers) has been associated with a significant clinical efficacy in …