Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
The role of neutrophils in autoimmune diseases
Though chronic autoimmune disorders such as rheumatoid arthritis or systemic lupus
erythematosus affect a significant percentage of the human population and strongly diminish …
erythematosus affect a significant percentage of the human population and strongly diminish …
Adacolumn, an Adsorptive Carrier Based Granulocyte and MonocyteApheresis Device for the Treatment of Inflammatory and RefractoryDiseases Associated with …
AR Saniabadi, H Hanai, K Takeuchi… - Therapeutic …, 2003 - Wiley Online Library
Apheresis has been recognized both economically and therapeuticallyas a novel approach
for the treatment of inflammatory diseases, and certain others, which respond poorly to drug …
for the treatment of inflammatory diseases, and certain others, which respond poorly to drug …
Safety and efficacy of granulocyte and monocyte adsorption apheresis in patients with active ulcerative colitis: a multicenter study
T Shimoyama, K Sawada, N Hiwatashi… - Journal of Clinical …, 2001 - Wiley Online Library
Active ulcerative colitis (UC) is characterized by activation and infiltration of granulocytes
and monocytes/macrophages into the colonic mucosa. The infiltrated leukocytes can cause …
and monocytes/macrophages into the colonic mucosa. The infiltrated leukocytes can cause …
A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis
BE Sands, WJ Sandborn, B Feagan, R Löfberg, T Hibi… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: Activated granulocytes and monocytes/macrophages are
implicated in the pathogenesis of ulcerative colitis. Open-label studies and clinical …
implicated in the pathogenesis of ulcerative colitis. Open-label studies and clinical …
Leukocyte adsorptive apheresis for the treatment of active ulcerative colitis: a prospective, uncontrolled, pilot study
H Hanai, F Watanabe, K Takeuchi, T Iida… - Clinical …, 2003 - Elsevier
Background & Aims: Active ulcerative colitis (UC) is characterized by infiltration of activated
granulocytes and monocytes/macrophages (GM) within the large bowel mucosa. GM are …
granulocytes and monocytes/macrophages (GM) within the large bowel mucosa. GM are …
Immunomodulatory effects of granulocyte and monocyte adsorption apheresis as a treatment for patients with ulcerative colitis
N Kashiwagi, K Sugimura, H Koiwai… - Digestive diseases and …, 2002 - Springer
Our aim was to understand the mechanism of immunological changes associated with the
use of an adsorptive-type extracorporeal device (Adacolumn) that has been developed for …
use of an adsorptive-type extracorporeal device (Adacolumn) that has been developed for …
Selective granulocyte and monocyte adsorptive apheresis as a first-line treatment for steroid naive patients with active ulcerative colitis: a prospective uncontrolled …
Y Suzuki, N Yoshimura, AR Saniabadi… - Digestive diseases and …, 2004 - Springer
Corticosteroid therapy of ulcerative colitis (UC) is associated with frequent adverse side
effects and poor quality of life. Recently, adsorptive granulocyte and monocyte/macrophage …
effects and poor quality of life. Recently, adsorptive granulocyte and monocyte/macrophage …
Adsorptive granulocyte and monocyte apheresis versus prednisolone in patients with corticosteroid-dependent moderately severe ulcerative colitis
H Hanai, F Watanabe, M Yamada, Y Sato, K Takeuchi… - Digestion, 1945 - karger.com
Background/Aim: Active ulcerative colitis (UC) is often associated with increased peripheral
granulocytes and monocytes/macrophages which show activation behavior and prolonged …
granulocytes and monocytes/macrophages which show activation behavior and prolonged …
Studies on the mechanisms of leukocyte adhesion to cellulose acetate beads: an in vitro model to assess the efficacy of cellulose acetate carrier‐based granulocyte …
K Hiraishi, Y Takeda, N Shiobara… - Therapeutic …, 2003 - Wiley Online Library
Granulocyte and monocyte adsorptive apheresis (GMA) using a column filled with cellulose
acetate (CA) beads (carriers) has been associated with a significant clinical efficacy in …
acetate (CA) beads (carriers) has been associated with a significant clinical efficacy in …