Since previous consensus-based Wilms tumour (WT) surveillance guidelines were
published, novel genes and syndromes associated with WT risk have been identified, and …

Simple Summary Beckwith–Wiedemann Syndrome (BWS) is one of the five most frequent
syndromes predisposing to Wilms tumor (WT). BWS can be underdiagnosed if the …

WAGR syndrome is a rare genetic disorder characterized by Wilms tumor, Aniridia,
Genitourinary anomalies, and Range of developmental delays. In addition to the classic …

Simple Summary It is well known that different cancer predisposition syndromes are
associated with characteristic WT-features. The following findings from our retrospective …

Beckwith–Wiedemann Spectrum (BWSp) is the most common epigenetic childhood cancer
predisposition disorder. BWSp is caused by (epi) genetic changes affecting the BWS critical …

Simple Summary Congenital lateralized or segmental overgrowth (LO) disorders are
conditions characterized by excessive tissue growth of a body region often associated with a …

Abstract Beckwith–Wiedemann spectrum, Simpson–Golabi–Behmel syndrome, familial
adenomatous polyposis and trisomy 18 are the most common congenital conditions …

Lateralized overgrowth (LO), or segmental overgrowth, is defined as an increase in growth
of tissue (bone, muscle, connective tissue, vasculature, etc.) in any region of the body. Some …

Historically, specific mutations in WT1 gene have been associated with distinct syndromes
based on phenotypic characteristics, including Denys-Drash syndrome (DDS), Frasier …

WT1 disorder is characterized by congenital/infantile or childhood onset of steroid-resistant
nephrotic syndrome (SRNS), a progressive glomerulopathy that does not respond to …