The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …

Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to
overcome environmental insults and respond to physiological cues. The mitochondrial …

A critical step in preserving protein homeostasis is the recognition, binding, unfolding, and
translocation of protein substrates by six AAA-ATPase proteasome subunits (ATPase …

Cells respond to viral infections through sensors that detect non-self-molecules, and through
effectors, which can have direct antiviral activities or adapt cell physiology to limit viral …

Biological aging can be described as accumulative, prolonged metabolic stress and is the
major risk factor for cognitive decline and Alzheimer's disease (AD). Recently, we identified …

Monkeypox is a zoonotic Orthopoxvirus which has predominantly affected humans living in
western and central Africa since the 1970s. Type I and II interferon signaling, NK cell …

Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …

Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes
(T1D), capable of inducing chronic inflammation and compromising b cell function. Here, we …

One of the most powerful and multifaceted cytokines produced by immune cells are type I
interferons (IFNs), the basal secretion of which contributes to the maintenance of immune …