Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer (CRC)
characterized by the presence of abundant extracellular mucin which accounts for at least …

Simple Summary Colorectal cancer accounts for approximately 10% of all annually
diagnosed cancers worldwide being liver metastasis, the most common cause of death in …

Tumors depend on a blood supply to deliver oxygen and nutrients, making tumor
vasculature an attractive anticancer target. However, only a fraction of patients with cancer …

Background: Expression of hypoxia-inducible factors (HIFs) has been observed, but their
prognostic role in advanced cancers remains uncertain. We conducted a meta-analysis to …

Hypoxia in cancer is a thoroughly studied phenomenon, and the logical cause of the
reduction in oxygen tension is tumor growth itself. While sustained hypoxia leads to death by …

Abstract B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory
protein expressed in immune cells, antigen-presenting cells, and tumor cells. Studies reveal …

Metastasis remains a notable issue in patients with newly diagnosed colorectal carcinomas
(CRC). Although anti‑angiogenic therapies target metastatic diseases, hypoxia‑inducible …

Novel predictive biomarkers are needed to improve patient selection and optimize the use of
bevacizumab (B) in metastatic colorectal cancer. We analyzed the potential of five circulating …

Objective To investigate the immunohistochemical expressions of HIF-1α, CA9 and CXCR4
in resected human CRC specimens in relation to clinicopathologic and prognostic variables …

Simple Summary In this study, we showed that the prognostic value of serum concentrations
and the tissue expressions of angiogenic growth factors VEGF, bFGF, and PDGF-bb vary …