Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment

TH Bisgaard, KH Allin, L Keefer… - Nature reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a
chronic, relapsing immune-mediated disease with a varying and sometimes severe disease …

The Lancet Commission on global mental health and sustainable development

V Patel, S Saxena, C Lund, G Thornicroft, F Baingana… - The lancet, 2018 - thelancet.com
Executive summary The Sustainable Development Goals (SDGs) represent an exponential
advance from the Millennium Development Goals, with a substantially broader agenda …

[HTML][HTML] Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

K Hashimoto - Molecular Psychiatry, 2023 - nature.com
The human body harbors a diverse ecosystem of microorganisms, including bacteria,
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …

A tutorial on conducting genome‐wide association studies: Quality control and statistical analysis

AT Marees, H De Kluiver, S Stringer… - … journal of methods …, 2018 - Wiley Online Library
Objectives Genome‐wide association studies (GWAS) have become increasingly popular to
identify associations between single nucleotide polymorphisms (SNPs) and phenotypic …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

[HTML][HTML] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders

PF Sullivan, DH Geschwind - Cell, 2019 - cell.com
Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …

Glutamate hypothesis in schizophrenia

Y Uno, JT Coyle - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an
individual's life and on society. Thus, developing more effective therapeutic interventions is …

[HTML][HTML] Genetic testing in neurodevelopmental disorders

JM Savatt, SM Myers - Frontiers in Pediatrics, 2021 - frontiersin.org
Neurodevelopmental disorders are the most prevalent chronic medical conditions
encountered in pediatric primary care. In addition to identifying appropriate descriptive …

Heritability of schizophrenia and schizophrenia spectrum based on the nationwide Danish twin register

R Hilker, D Helenius, B Fagerlund, A Skytthe… - Biological …, 2018 - Elsevier
Background Twin studies have provided evidence that both genetic and environmental
factors contribute to schizophrenia (SZ) risk. Heritability estimates of SZ in twin samples …

Genetic identification of brain cell types underlying schizophrenia

NG Skene, J Bryois, TE Bakken, G Breen, JJ Crowley… - Nature …, 2018 - nature.com
With few exceptions, the marked advances in knowledge about the genetic basis of
schizophrenia have not converged on findings that can be confidently used for precise …