[HTML][HTML] Past, present and future—β2-adrenoceptor agonists in asthma management

MR Sears, J Lötvall - Respiratory medicine, 2005 - Elsevier
The β-adrenoceptor agonists (β-agonists) have been used to relieve bronchoconstriction for
at least 5000 years. β-agonists are based on adrenaline and early forms, such as …

The β2-agonist controversy: observations, explanations and relationship to asthma epidemiology

MR Sears, DR Taylor - Drug Safety, 1994 - Springer
Links between frequent use of inhaled β2-agonists and morbidity and mortality from asthma
appear probable. Two mortality epidemics followed the marketing of potent inhaled …

Regular inhaled beta-agonist treatment in bronchial asthma

MR Sears, DR Taylor, CG Print, DC Lake, Q Li… - The Lancet, 1990 - Elsevier
Abstract 89 subjects with stable asthma took part in a double-blind, placebo-controlled,
randomised, crossover study of the effects of regular versus on-demand inhaled …

Comparison of regularly scheduled with as-needed use of albuterol in mild asthma

JM Drazen, E Israel, HA Boushey… - … England Journal of …, 1996 - Mass Medical Soc
Background Inhaled β-agonists are the most commonly used treatment for asthma, but data
suggest that regularly scheduled use of these agents may have a deleterious effect on the …

[图书][B] Innovation in the pharmaceutical industry: the process of drug discovery and development

T Hara - 2003 - books.google.com
" Addressing a number of practical implications for the promotion of the pharmaceutical
industry, this book will be of enormous interest to students, researchers and academics …

Albuterol: an adrenergic agent for use in the treatment of asthma pharmacology, pharmacokinetics and clinical use

RC Ahrens, GD Smith - Pharmacotherapy: The Journal of …, 1984 - Wiley Online Library
Albuterol is a long‐acting beta2‐adrenergic receptor‐selective drug that relaxes airway
smooth muscle. It is currently available in the United States in oral and metered‐dose …

The beta-agonist controversy

DR Taylor, MR Sears, DW Cockcroft - Medical Clinics, 1996 - medical.theclinics.com
BACKGROUND Despite widespread use of adrenergic agents in the management of
asthma for many decades, doubts have emerged concerning the safety and efficacy of long …

Inhaled short acting beta2‐agonist use in chronic asthma: regular versus as needed treatment

EH Walters, JAE Walters, PG Gibson… - Cochrane Database …, 1996 - cochranelibrary.com
Background Inhaled short‐acting beta‐2 agonists are the major class of bronchodilators
used for relief of symptoms in asthma. There has been concern that excessive uncontrolled …

Pharmacological management of mild or moderate persistent asthma

PM O'Byrne, K Parameswaran - The Lancet, 2006 - thelancet.com
Patients with mild persistent asthma rarely see their doctor with symptoms of the disease.
Partly as a result of this situation, mild asthma is generally undertreated. Findings of several …

Major reduction in asthma morbidity and continued reduction in asthma mortality in New Zealand: what lessons have been learned?

J Garrett, J Kolbe, G Richards, T Whitlock, H Rea - Thorax, 1995 - thorax.bmj.com
Increasing financial barriers to primary health care against a background of social and
economic decline are likely to have contributed to asthma morbidity and mortality in New …