Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Objective: Postpartum depression (PPD) is a common perinatal complication with adverse
maternal and infant outcomes. This study investigated the efficacy and safety of zuranolone …

Despite considerable progress in pharmacotherapy over the past seven decades, many
mental disorders remain insufficiently treated. This situation is in part due to the limited …

The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

In the past 20 years, our understanding of the pathophysiology of depression has evolved
from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture …

This article reviews novel neurosteroid therapeutics for post-partum depression, with a focus
on their development, clinical trial data, current practices, and future directions in this …

Objective: This study assessed the efficacy and safety of a 14-day treatment course of once-
daily zuranolone 50 mg, an investigational oral positive allosteric modulator of the γ …

In contrast to most fields of medicine, progress to discover and develop new and improved
psychiatric drugs has been slow and disappointing. The vast majority of currently prescribed …

Major depressive disorder (MDD) is a chronic relapsing psychiatric disorder. Conventional
antidepressants usually require several weeks of continuous administration to exert …