Metabolism and metabolites of polychlorinated biphenyls

FA Grimm, D Hu, I Kania-Korwel… - Critical reviews in …, 2015 - Taylor & Francis
The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on
toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable …

Polybrominated diphenyl ether (PBDE) neurotoxicity: a systematic review and meta-analysis of animal evidence

DC Dorman, W Chiu, BF Hales, R Hauser… - Journal of Toxicology …, 2018 - Taylor & Francis
ABSTRACT A recent systematic review (SR) and meta-analysis of human studies found an
association between prenatal serum polybrominated diphenyl ethers (PBDE) concentrations …

Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs)

K Dhakal, GS Gadupudi, HJ Lehmler… - … Science and Pollution …, 2018 - Springer
Polychlorinated biphenyls (PCBs), a group of 209 congeners that differ in the number and
position of chlorines on the biphenyl ring, are anthropogenic chemicals that belong to the …

Metabolism of 3-chlorobiphenyl (PCB 2) in a human-relevant cell line: evidence of dechlorinated metabolites

CY Zhang, X Li, S Flor, P Ruiz, A Kruve… - … science & technology, 2022 - ACS Publications
Lower chlorinated polychlorinated biphenyls (LC-PCBs) and their metabolites make up a
class of environmental pollutants implicated in a range of adverse outcomes in humans; …

PCBs and OH-PCBs in polar bear mother–cub pairs: a comparative study based on plasma levels in 1998 and 2008

J Bytingsvik, E Lie, J Aars, AE Derocher, Ø Wiig… - Science of the Total …, 2012 - Elsevier
The aim of this study was to examine the plasma concentrations and prevalence of
polychlorinated biphenyls (PCBs) and hydroxylated PCB-metabolites (OH-PCBs) in polar …

Machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples

CY Zhang, X Li, KP Keil Stietz, S Sethi… - … science & technology, 2022 - ACS Publications
Laboratory studies of the disposition and toxicity of hydroxylated polychlorinated biphenyl
(OH-PCB) metabolites are challenging because authentic analytical standards for most …

The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats

RM Steinberg, TE Juenger, AC Gore - Hormones and behavior, 2007 - Elsevier
Polychlorinated biphenyls (PCBs) are a family of toxicants that persist in measurable
quantities in human and wildlife tissues, despite their ban in production in 1977. Some PCB …

Endocrine disruptors and female fertility: focus on (bovine) ovarian follicular physiology

EML Petro, J Leroy, SJM Van Cruchten, A Covaci… - Theriogenology, 2012 - Elsevier
Throughout the previous century, the production, use and, as a result, presence of chemicals
in the environment increased enormously. Consequently, humans and animals are exposed …

Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats

K Dhakal, E Uwimana… - Chemical research in …, 2014 - ACS Publications
PCBs, such as PCB3, are air contaminants in buildings and outdoors. Metabolites of PCB3
are potential endocrine disrupting chemicals and genotoxic agents. We studied the …

Interconversion between methoxylated and hydroxylated polychlorinated biphenyls in rice plants: an important but overlooked metabolic pathway

J Sun, L Pan, Z Su, Y Zhan, L Zhu - Environmental Science & …, 2016 - ACS Publications
To date, there is limited knowledge on the methoxylation of polychlorinated biphenyls
(PCBs) and the relationship between hydroxylated polychlorinated biphenyls (OH-PCBs) …