Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …

Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained
extensive exploration due to its unique structure features and multiple promising biological …

Overweight and obesity have become global epidemics, especially during the lockdown due
to the COVID-19 pandemic. The potential of medicinal plants as a better and safe option in …

Celastrol, a quinone‐methide triterpenoid, was extracted from Tripterygium wilfordii Hook. F.
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …

Cerebral ischemia/reperfusion (I/R) injury is closely related to dysfunctional glucose
metabolism. Celastrol is a bioactive compound that has been found to exhibit …

Cardiovascular diseases (CVD) are leading causes of morbidity and mortality worldwide;
therefore, seeking effective therapeutics to reduce the global burden of CVD has become …

Natural products and synthetic analogs have drawn much attention as potential
therapeutical drugs to treat metabolic syndrome. We reviewed the underlying mechanisms …

Celastrol, a compound extracted from traditional Chinese medicine, has been reported as a
potent anti-obesity agent with controversial mechanisms. Here both C57BL/6J and leptin …

Accumulating evidence indicates that adipose tissue inflammation and mitochondrial
dysfunction in skeletal muscle are inextricably linked to obesity and insulin resistance …

Chronic manganese (Mn) exposure can disturb mitochondrial homeostasis leading to
mitochondrial dysfunction, which is involved in Mn‐induced neurodegenerative diseases …