Spotlight on HIV-derived TAT peptide as a molecular shuttle in drug delivery

Z Maani, L Rahbarnia, A Bahadori, KM Chollou… - Drug Discovery …, 2024 - Elsevier
HIV-derived TAT peptide, with a high penetration rate into cells and its nonimmunogenic and
minimally toxic nature, is an attractive tool for enhancing the biodistribution of drugs and …

An injectable adhesive hydrogel for photothermal ablation and antitumor immune activation against bacteria-associated oral squamous cell carcinoma

L Bai, M Yang, J Wu, R You, Q Chen, Y Cheng, Z Qian… - Acta Biomaterialia, 2024 - Elsevier
Pathogenic bacteria are closely associated with the occurrence, development and
metastasis of oral squamous cell carcinoma (OSCC). Antibacterial therapy has been …

Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells

Y Kawaguchi, S Futaki - Current Opinion in Chemical Biology, 2024 - Elsevier
The delivery of functional proteins, including antibodies, into cells opens up many
opportunities to regulate cellular events, with significant implications for studies in chemical …

Polyresorcinols for intracellular protein delivery

Y Li, X Yu, Q Chen, H Wang, J Lv, Y Cheng - Nano Today, 2024 - Elsevier
Developing protein delivery systems holds tremendous promise for the next-generation of
protein-related biotechniques and biotherapeutics. Polycatechols inspired from nature …

Intracellular delivery strategies using membrane-interacting peptides and proteins

L Mai, S Wimberley, JA Champion - Nanoscale, 2024 - pubs.rsc.org
While the cellular cytosol and organelles contain attractive targets for disease treatments, it
remains a challenge to deliver therapeutic biomacromolecules to these sites. This is due to …

E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery

Y Kawaguchi, Y Kawamura, H Hirose… - Journal of Controlled …, 2024 - Elsevier
To facilitate the introduction of proteins, such as antibodies, into cells, a variety of delivery
peptides have been engineered. These peptides are typically highly cationic and somewhat …

Homologous polydopamine ameliorates haemolysis of melittin for enhancing its anticancer efficacy

Y Zheng, Q Wei, X Han, X Tao, T Cao, T Chen… - Journal of Materials …, 2024 - pubs.rsc.org
Despite exhibiting potent anticancer activity, the strong hemolytic properties of melittin (MEL)
significantly restrict its delivery efficiency and clinical applications. To address this issue, we …

Liquid Droplet-Mediated Formulation of Lipid Nanoparticles Encapsulating Immunoglobulin G for Cytosolic Delivery

Y Hirai, Y Kawaguchi, C Kasahara… - Molecular …, 2024 - ACS Publications
Antibodies are promising biopharmaceuticals that offer new therapeutic options for
diseases. Since antibodies are membrane impermeable, approaches that allow …

Rational design of oral delivery nanosystems for hypoglycemic peptides

T Peng, X Shao, L Long, H Liu, W Song, J Hou… - Nano Today, 2023 - Elsevier
Hypoglycemic peptides have exhibited great clinical benefits for diabetics and body weight
control due to their high activity, high specificity, and low toxicity. However, frequent …

Dual-mRNA Delivery Using Tumor Cell Lysate-Based Multifunctional Nanoparticles as an Efficient Colon Cancer Immunogene Therapy

K Wang, Y Gao, S Wu, J Zhang, M Zhu… - International Journal …, 2024 - Taylor & Francis
Background Messenger RNA (mRNA)-based immunogene therapy holds significant
promise as an emerging tumor therapy approach. However, the delivery efficiency of …