[HTML][HTML] Neuro-inflammation modulation and post-traumatic brain injury lesions: from bench to bed-side

A Jacquens, EJ Needham, ER Zanier, V Degos… - International journal of …, 2022 - mdpi.com
Head trauma is the most common cause of disability in young adults. Known as a silent
epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor …

[HTML][HTML] Traumatic brain injury: an age-dependent view of post-traumatic neuroinflammation and its treatment

C Delage, T Taib, C Mamma, D Lerouet, VC Besson - Pharmaceutics, 2021 - mdpi.com
Traumatic brain injury (TBI) is a leading cause of death and disability all over the world. TBI
leads to (1) an inflammatory response,(2) white matter injuries and (3) neurodegenerative …

[HTML][HTML] Progesterone attenuates neurological deficits and exerts a protective effect on damaged axons via the PI3K/AKT/mTOR-dependent pathway in a mouse …

C Liu, W Gao, L Zhao, Y Cao - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Intracerebral hemorrhage (ICH) is a devastating event with high disability and fatality rates.
However, there is a lack of effective treatments for this condition. We aimed to investigate the …

[HTML][HTML] Network pharmacology and topological analysis on tibolone metabolites and their molecular mechanisms in traumatic brain injury

GE Barreto, J Gonzalez, D Ramírez - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Traumatic brain injury (TBI) is a pathology of great social impact, affecting millions of people
worldwide. Despite the scientific advances to improve the management of TBI in recent …

[HTML][HTML] Therapy of traumatic brain injury by modern agents and traditional Chinese medicine

C Wei, J Wang, J Yu, Q Tang, X Liu, Y Zhang, D Cui… - Chinese medicine, 2023 - Springer
Traumatic brain injury (TBI) is the leading cause of disability and death, and the social
burden of mortality and morbidity caused by TBI is significant. Under the influence of …

Mild traumatic brain injury affects orexin/hypocretin physiology differently in male and female mice

RT Somach, ID Jean, AM Farrugia… - Journal of …, 2023 - liebertpub.com
Traumatic brain injury (TBI) is known to affect the physiology of neural circuits in several
brain regions, which can contribute to behavioral changes after injury. Disordered sleep is a …

Pediatric traumatic brain injury and a subsequent transient immune challenge independently influenced chronic outcomes in male mice

R Sharma, PM Casillas-Espinosa, LK Dill… - Brain, behavior, and …, 2022 - Elsevier
Traumatic brain injury (TBI) is a major contributor to death and disability worldwide. Children
are at particularly high risk of both sustaining a TBI and experiencing serious long-term …

Glucocorticoid receptor overexpression in the dorsal hippocampus attenuates spatial learning and synaptic plasticity deficits after pediatric traumatic brain injury

D Lengel, ZL Romm, A Bostwick, JW Huh… - Journal of …, 2022 - liebertpub.com
Traumatic brain injury (TBI) in children< 4 years of age leads to long-term deficits in
cognitive and learning abilities that can persist or even worsen as these children age into …

Intranasal administration of oxytocin attenuates social recognition deficits and increases prefrontal cortex inhibitory postsynaptic currents following traumatic brain …

A Runyan, D Lengel, JW Huh, JR Barson… - Eneuro, 2021 - eneuro.org
Pediatric traumatic brain injury (TBI) results in heightened risk for social deficits that can
emerge during adolescence and adulthood. A moderate TBI in male and female rats on …

[HTML][HTML] Do astrocytes act as immune cells after pediatric TBI?

PE Panchenko, L Hippauf, JP Konsman… - Neurobiology of disease, 2023 - Elsevier
Astrocytes are in contact with the vasculature, neurons, oligodendrocytes and microglia,
forming a local network with various functions critical for brain homeostasis. One of the …